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Page 1
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Zhang L, Yu X, Zheng L, Zhang Y, Li Y, Fang Q, Gao R, Kang B, Zhang Q, Huang JY, Konno H, Guo X, Ye Y, Gao S, Wang S, Hu X, Ren X, Shen Z, Ouyang W, Zhang Z. Zhang L, et al. Nature. 2018 Dec;564(7735):268-272. doi: 10.1038/s41586-018-0694-x. Epub 2018 Oct 29. Nature. 2018. PMID: 30479382
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T cells within tumours, remain unknown. ...Our integrated STARTRAC analyses provide a powerful approach to dissect the T cell properties in colo …
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T ce …
Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.
Liu ZX, Zhang XL, Zhao Q, Chen Y, Sheng H, He CY, Sun YT, Lai MY, Wu MQ, Zuo ZX, Wang W, Zhou ZW, Wang FH, Li YH, Xu RH, Qiu MZ. Liu ZX, et al. JAMA Netw Open. 2022 Dec 1;5(12):e2245836. doi: 10.1001/jamanetworkopen.2022.45836. JAMA Netw Open. 2022. PMID: 36484990 Free PMC article.
IMPORTANCE: The E-cadherin gene, CDH1, and the alpha-E-catenin gene, CTNNA1, were previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes, explaining 25% to 50% of HDGC cases. ...The genes with the highest incidence (>10%) of private germl …
IMPORTANCE: The E-cadherin gene, CDH1, and the alpha-E-catenin gene, CTNNA1, were previously identified as hereditary diffuse gastric can …
Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma.
Verma SP, Das P. Verma SP, et al. PLoS One. 2018 Oct 18;13(10):e0205660. doi: 10.1371/journal.pone.0205660. eCollection 2018. PLoS One. 2018. PMID: 30335789 Free PMC article.
The IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) gene has a role in skeletal muscle function and is also involved in metastatic breast cancer, and the isoforms with three N-terminal globular domains are sufficient for its function in skel …
The IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) gene has a role in skeletal muscle function and is also …
Recognition of a Novel Gene Signature for Human Glioblastoma.
Lu CH, Wei ST, Liu JJ, Chang YJ, Lin YF, Yu CS, Chang SL. Lu CH, et al. Int J Mol Sci. 2022 Apr 9;23(8):4157. doi: 10.3390/ijms23084157. Int J Mol Sci. 2022. PMID: 35456975 Free PMC article.
The 33 identified signature genes included the overexpressed genes COL6A2, ABCC3, COL8A1, FAM20A, ADM, CTHRC1, PDPN, IBSP, MIR210HG, GPX8, MYL9 and PDLIM4, as well as the underexpressed genes CHST9, CSDC2, ENHO, FERMT1, IGFN1, LINC00836, MGAT4C, SHANK2 and VIPR2. Protein f …
The 33 identified signature genes included the overexpressed genes COL6A2, ABCC3, COL8A1, FAM20A, ADM, CTHRC1, PDPN, IBSP, MIR210HG, GPX8, M …
Identification and Prognostic Value Exploration of Radiotherapy Sensitivity-Associated Genes in Non-Small-Cell Lung Cancer.
Ma Q, Geng K, Xiao P, Zeng L. Ma Q, et al. Biomed Res Int. 2021 Sep 2;2021:5963868. doi: 10.1155/2021/5963868. eCollection 2021. Biomed Res Int. 2021. PMID: 34518802 Free PMC article.
BACKGROUND: Non-small-cell lung cancer (NSCLC) is a prevalent malignancy with high mortality and poor prognosis. ...METHODS: The NSCLC samples with radiotherapy records were obtained from The Cancer Genome Atlas database, and the mRNA expression profiles of NSCLC pa …
BACKGROUND: Non-small-cell lung cancer (NSCLC) is a prevalent malignancy with high mortality and poor prognosis. ...METHODS: The NSCL …
Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.
Lefebvre C, Bachelot T, Filleron T, Pedrero M, Campone M, Soria JC, Massard C, Lévy C, Arnedos M, Lacroix-Triki M, Garrabey J, Boursin Y, Deloger M, Fu Y, Commo F, Scott V, Lacroix L, Dieci MV, Kamal M, Diéras V, Gonçalves A, Ferrerro JM, Romieu G, Vanlemmens L, Mouret Reynier MA, Théry JC, Le Du F, Guiu S, Dalenc F, Clapisson G, Bonnefoi H, Jimenez M, Le Tourneau C, André F. Lefebvre C, et al. PLoS Med. 2016 Dec 27;13(12):e1002201. doi: 10.1371/journal.pmed.1002201. eCollection 2016 Dec. PLoS Med. 2016. PMID: 28027327 Free PMC article.
BACKGROUND: Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. ...METH …
BACKGROUND: Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breas …
The value of erlotinib related target molecules in kidney renal cell carcinoma via bioinformatics analysis.
Zhang Y, Tang M, Guo Q, Xu H, Yang Z, Li D. Zhang Y, et al. Gene. 2022 Mar 30;816:146173. doi: 10.1016/j.gene.2021.146173. Epub 2022 Jan 11. Gene. 2022. PMID: 35026294
RESULTS: Following erlotinib treatment, DEGs were involved in antigen binding, myeloid leukocyte activation, JAK-STAT signaling pathway, etc. COL11A1, EMCN, GLYATL1, HHLA2, IGFN1, LIPA, LRRC19, PANK1, PRAME, and TNFSF14 were independent factors influencing poor prognosis i …
RESULTS: Following erlotinib treatment, DEGs were involved in antigen binding, myeloid leukocyte activation, JAK-STAT signaling pathway, etc …
Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.
Miao C, Liu D, Zhang F, Wang Y, Zhang Y, Yu J, Zhang Z, Liu G, Li B, Liu X, Luo C. Miao C, et al. Sci Rep. 2015 Mar 13;5:9079. doi: 10.1038/srep09079. Sci Rep. 2015. PMID: 25765001 Free PMC article.
We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primar …
We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and …
Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma.
Si J, Huang B, Lan G, Zhang B, Wei J, Deng Z, Li Y, Qin Y, Li B, Lu Y, Si Y. Si J, et al. Transl Cancer Res. 2020 Jul;9(7):4080-4092. doi: 10.21037/tcr-19-2899. Transl Cancer Res. 2020. PMID: 35117778 Free PMC article.
BACKGROUND: Nasopharyngeal carcinoma (NPC) is one of the most common cancers. To investigate the gene mutation profile of NPC patients, we performed whole exome sequencing (WES) in tumor cells, peripheral blood cells, and circulating tumor cells (CTCs) of primitive and met …
BACKGROUND: Nasopharyngeal carcinoma (NPC) is one of the most common cancers. To investigate the gene mutation profile of NPC patient …