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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 7
1999 18
2000 34
2001 52
2002 55
2003 61
2004 78
2005 68
2006 110
2007 105
2008 124
2009 111
2010 138
2011 155
2012 146
2013 129
2014 110
2015 125
2016 105
2017 111
2018 109
2019 86
2020 92
2021 81
2022 67
2023 53
2024 22

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2,097 results

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Page 1
Signaling via the NFκB system.
Mitchell S, Vargas J, Hoffmann A. Mitchell S, et al. Wiley Interdiscip Rev Syst Biol Med. 2016 May;8(3):227-41. doi: 10.1002/wsbm.1331. Epub 2016 Mar 16. Wiley Interdiscip Rev Syst Biol Med. 2016. PMID: 26990581 Free PMC article. Review.
The nuclear factor kappa B (NFkappaB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFkappaB signaling system (defined by the interactions between NFkappaB dimers, IkappaB regulators, and IKK compl …
The nuclear factor kappa B (NFkappaB) family of transcription factors is a key regulator of immune development, immune responses, inflammati …
Characterization of a small-molecule inhibitor targeting NEMO/IKKbeta to suppress colorectal cancer growth.
Yu Z, Gao J, Zhang X, Peng Y, Wei W, Xu J, Li Z, Wang C, Zhou M, Tian X, Feng L, Huo X, Liu M, Ye M, Guo DA, Ma X. Yu Z, et al. Signal Transduct Target Ther. 2022 Mar 9;7(1):71. doi: 10.1038/s41392-022-00888-1. Signal Transduct Target Ther. 2022. PMID: 35260565 Free PMC article.
It destabilizes IKKbeta/NEMO complex with IC(50) of 174 nM, thereby significantly impairing the proliferation of colorectal cancer cells by suppressing the NF-kappaB pathway in vitro and in vivo. ...
It destabilizes IKKbeta/NEMO complex with IC(50) of 174 nM, thereby significantly impairing the proliferation of colorectal cancer ce …
ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression.
Li N, Liu Q, Han Y, Pei S, Cheng B, Xu J, Miao X, Pan Q, Wang H, Guo J, Wang X, Zhang G, Lian Y, Zhang W, Zang Y, Tan M, Li Q, Wang X, Xiao Y, Hu G, Jiang J, Huang H, Qin J. Li N, et al. Nat Commun. 2022 Nov 26;13(1):7281. doi: 10.1038/s41467-022-34871-9. Nat Commun. 2022. PMID: 36435834 Free PMC article.
Chronic inflammation and an immunosuppressive microenvironment promote prostate cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) therapies. ...
Chronic inflammation and an immunosuppressive microenvironment promote prostate cancer (PCa) progression and diminish the response to …
MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression.
Tang X, Jin L, Cao P, Cao K, Huang C, Luo Y, Ma J, Shen S, Tan M, Li X, Zhou M. Tang X, et al. Oncotarget. 2016 Apr 26;7(17):23668-83. doi: 10.18632/oncotarget.8056. Oncotarget. 2016. PMID: 26993770 Free PMC article.
Up-regulation of IKBKB suppressed Taxol-induced apoptosis and led to an increased resistance to Taxol, and restoring IKBKB expression in miR-16-overexpressing breast cancer cells recovered Taxol resistance. ...Taken together, our data demonstrates that miR-16 …
Up-regulation of IKBKB suppressed Taxol-induced apoptosis and led to an increased resistance to Taxol, and restoring IKBKB exp …
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis.
Li F, Liang H, You H, Xiao J, Xia H, Chen X, Huang M, Cheng Z, Yang C, Liu W, Zhang H, Zeng L, Wu Y, Ge F, Li Z, Zhou W, Wen Y, Zhou Z, Liu R, Jiang D, Xie N, Liang B, Liu Z, Kong Y, Chen C. Li F, et al. Signal Transduct Target Ther. 2022 Aug 3;7(1):264. doi: 10.1038/s41392-022-01057-0. Signal Transduct Target Ther. 2022. PMID: 35918322 Free PMC article.
Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis. ...
Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion mo …
The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.
Gu L, Zhu Y, Lin X, Lu B, Zhou X, Zhou F, Zhao Q, Prochownik EV, Li Y. Gu L, et al. Hepatology. 2021 Jan;73(1):160-174. doi: 10.1002/hep.31249. Epub 2020 Nov 6. Hepatology. 2021. PMID: 32221968
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death that develops as a consequence of obesity, cirrhosis, and chronic hepatitis. ...
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death that develops as a consequence of obes …
Targeting IkappaappaB kinases for cancer therapy.
Awasthee N, Rai V, Chava S, Nallasamy P, Kunnumakkara AB, Bishayee A, Chauhan SC, Challagundla KB, Gupta SC. Awasthee N, et al. Semin Cancer Biol. 2019 Jun;56:12-24. doi: 10.1016/j.semcancer.2018.02.007. Epub 2018 Feb 24. Semin Cancer Biol. 2019. PMID: 29486318 Free PMC article. Review.
The dysregulation in the activities of these kinases has been reported in several cancer types. These kinases are known to regulate survival, proliferation, invasion, angiogenesis, and metastasis of cancer cells. ...In this review, we discuss the utility of IKK inhi …
The dysregulation in the activities of these kinases has been reported in several cancer types. These kinases are known to regulate s …
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development.
Wang X, Liu R, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G, Yang W. Wang X, et al. Mol Cell. 2019 Oct 3;76(1):148-162.e7. doi: 10.1016/j.molcel.2019.07.007. Epub 2019 Aug 22. Mol Cell. 2019. PMID: 31447391 Free article.
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Cancer cells often rewire their metabolic pathways for adaption to nutrient stress, and the underlying mechanism remains largely unknown. . …
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Can …
IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis.
Xie W, Jiang Q, Wu X, Wang L, Gao B, Sun Z, Zhang X, Bu L, Lin Y, Huang Q, Li J, Guo J. Xie W, et al. Cell Death Differ. 2022 Aug;29(8):1528-1540. doi: 10.1038/s41418-022-00940-1. Epub 2022 Jan 22. Cell Death Differ. 2022. PMID: 35066576 Free PMC article.
IKBKE, a non-canonical inflammatory kinase, is frequently amplified or activated, and plays predominantly oncogenic roles in human cancers, especially in breast cancer. However, the potential function and underlying mechanism of IKBKE contributing to breast cance …
IKBKE, a non-canonical inflammatory kinase, is frequently amplified or activated, and plays predominantly oncogenic roles in human cancer …
Metformin, aging and cancer.
Moiseeva O, Deschênes-Simard X, Pollak M, Ferbeyre G. Moiseeva O, et al. Aging (Albany NY). 2013 May;5(5):330-1. doi: 10.18632/aging.100556. Aging (Albany NY). 2013. PMID: 23660016 Free PMC article. No abstract available.
2,097 results