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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1986 2
1994 4
1995 40
1996 89
1997 105
1998 145
1999 147
2000 178
2001 202
2002 228
2003 227
2004 238
2005 269
2006 277
2007 281
2008 305
2009 316
2010 317
2011 358
2012 345
2013 344
2014 360
2015 339
2016 378
2017 356
2018 398
2019 375
2020 453
2021 509
2022 478
2023 453
2024 195

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7,839 results

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Page 1
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer.
Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, Pareek S, Rajaei H, Mohindroo C, Baydogan S, Ngo-Huang A, Parker N, Katz MHG, Petzel M, Vucic E, McAllister F, Schadler K, Winograd R, Bar-Sagi D. Kurz E, et al. Cancer Cell. 2022 Jul 11;40(7):720-737.e5. doi: 10.1016/j.ccell.2022.05.006. Epub 2022 Jun 2. Cancer Cell. 2022. PMID: 35660135 Free PMC article.
Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma.
Nguyen R, Zhang X, Sun M, Abbas S, Seibert C, Kelly MC, Shern JF, Thiele CJ. Nguyen R, et al. Clin Cancer Res. 2022 Sep 1;28(17):3785-3796. doi: 10.1158/1078-0432.CCR-22-0717. Clin Cancer Res. 2022. PMID: 35802683 Free PMC article.
We developed two new immunocytokines (IC) by linking two other gammac cytokines, IL15 and IL21, to hu14.18. The purpose of this study was to compare hu14.18-IL15 and -IL21 with hu14.18-IL2 in their ability to induce antibody-dependent cell-mediated cytotoxicity (ADC …
We developed two new immunocytokines (IC) by linking two other gammac cytokines, IL15 and IL21, to hu14.18. The purpose of this study …
Interleukin 15: A key cytokine for immunotherapy.
Patidar M, Yadav N, Dalai SK. Patidar M, et al. Cytokine Growth Factor Rev. 2016 Oct;31:49-59. doi: 10.1016/j.cytogfr.2016.06.001. Epub 2016 Jun 7. Cytokine Growth Factor Rev. 2016. PMID: 27325459 Review.
A novel multimeric IL15/IL15Ralpha-Fc complex to enhance cancer immunotherapy.
Xu H, Buhtoiarov IN, Guo H, Cheung NV. Xu H, et al. Oncoimmunology. 2021 Mar 11;10(1):1893500. doi: 10.1080/2162402X.2021.1893500. Oncoimmunology. 2021. PMID: 33763293 Free PMC article.
Several IL15-cytokine fusion proteins have been developed to improve their in vivo function, typically exploiting the IL15Ralpha to complex with IL15, to extend serum half-life and increase affinity for IL15beta receptor on immune cells. Here we describe a novel …
Several IL15-cytokine fusion proteins have been developed to improve their in vivo function, typically exploiting the IL15Ralpha to c …
IL-15 in the Combination Immunotherapy of Cancer.
Waldmann TA, Dubois S, Miljkovic MD, Conlon KC. Waldmann TA, et al. Front Immunol. 2020 May 19;11:868. doi: 10.3389/fimmu.2020.00868. eCollection 2020. Front Immunol. 2020. PMID: 32508818 Free PMC article. Review.
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy.
Waldmann TA. Waldmann TA. Cancer Immunol Res. 2015 Mar;3(3):219-27. doi: 10.1158/2326-6066.CIR-15-0009. Cancer Immunol Res. 2015. PMID: 25736261 Free PMC article. Review.
IL2 and IL15, members of the 4alpha-helix bundle family of cytokines, play pivotal roles in the control of the life and death of lymphocytes. ...Furthermore, clinical trials are being initiated that employ the combination of IL15 with IL15Ralpha(+/-) IgFc....
IL2 and IL15, members of the 4alpha-helix bundle family of cytokines, play pivotal roles in the control of the life and death of lymp …
A Novel Antibody-IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis.
Corbellari R, Stringhini M, Mock J, Ongaro T, Villa A, Neri D, De Luca R. Corbellari R, et al. Mol Cancer Ther. 2021 May;20(5):859-871. doi: 10.1158/1535-7163.MCT-20-0853. Epub 2021 Feb 25. Mol Cancer Ther. 2021. PMID: 33632875 Free PMC article.
Most recently, the Sushi Domain (SD, the shortest region of IL15 receptor alpha, capable of binding to IL15) has been fused to IL15-based anticancer products to increase its biological activity. ...Unlike previously described fusions of the F8 antibody with h …
Most recently, the Sushi Domain (SD, the shortest region of IL15 receptor alpha, capable of binding to IL15) has been fused to …
Quercetin downregulates the expression of IL15 in cancer cells through DNA methylation.
Zhang M, Lu A, Wang H, Yang J. Zhang M, et al. Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2580-2590. doi: 10.26355/eurrev_202303_31795. Eur Rev Med Pharmacol Sci. 2023. PMID: 37013776 Free article.
RESULTS: Following quercetin treatment, the expression of IL15 was significantly downregulated in HeLa and A549 cells. The methylation level of IL15 promoter in HeLa cells was about twice that of the control group, and the methylation level of IL15 promoter i …
RESULTS: Following quercetin treatment, the expression of IL15 was significantly downregulated in HeLa and A549 cells. The methylatio …
PES1 reduces CD8(+) T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma.
Ma N, Hua R, Yang Y, Liu ZC, Pan J, Yu BY, Sun YF, Xie D, Wang Y, Li ZG. Ma N, et al. J Biomed Sci. 2023 Mar 23;30(1):20. doi: 10.1186/s12929-023-00912-8. J Biomed Sci. 2023. PMID: 36959575 Free PMC article.
Analyses on RNA sequencing and mass spectrometry suggested that PES1 expression was negatively correlated with IL15 and ILF3 was one of the PES1-associated proteins. It has been known that ILF3 interacts with and stabilizes IL15 mRNA to increase IL15 protein …
Analyses on RNA sequencing and mass spectrometry suggested that PES1 expression was negatively correlated with IL15 and ILF3 was one …
Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models.
Mu-Mosley H, Ostermann L, Muftuoglu M, Vaidya A, Bonifant CL, Velasquez MP, Gottschalk S, Andreeff M. Mu-Mosley H, et al. Front Immunol. 2022 May 9;13:880108. doi: 10.3389/fimmu.2022.880108. eCollection 2022. Front Immunol. 2022. PMID: 35615350 Free PMC article.
We therefore set out to explore whether transgenic expression of IL15 improves the effector function of ENG T-cells targeting CD123-positive AML. T-cells expressing CD123-specific ENG (CD123-ENG) IL15 were generated by retroviral transduction from peripheral blood T …
We therefore set out to explore whether transgenic expression of IL15 improves the effector function of ENG T-cells targeting CD123-p …
7,839 results