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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1995 1
1996 2
1997 3
1998 3
1999 2
2000 4
2001 9
2002 13
2003 16
2004 18
2005 26
2006 30
2007 29
2008 25
2009 32
2010 32
2011 35
2012 39
2013 63
2014 100
2015 124
2016 97
2017 116
2018 117
2019 180
2020 212
2021 198
2022 146
2023 131
2024 69

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1,650 results

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Page 1
Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer.
Li J, Wu C, Hu H, Qin G, Wu X, Bai F, Zhang J, Cai Y, Huang Y, Wang C, Yang J, Luan Y, Jiang Z, Ling J, Wu Z, Chen Y, Xie Z, Deng Y. Li J, et al. Cancer Cell. 2023 Jun 12;41(6):1152-1169.e7. doi: 10.1016/j.ccell.2023.04.011. Epub 2023 May 11. Cancer Cell. 2023. PMID: 37172580
Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs). However, the underlying mechanism for pathological complete response (pCR) to immunotherapy has …
Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch repair-deficient and microsatellite instability-high (d- …
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer.
Li R, Ferdinand JR, Loudon KW, Bowyer GS, Laidlaw S, Muyas F, Mamanova L, Neves JB, Bolt L, Fasouli ES, Lawson ARJ, Young MD, Hooks Y, Oliver TRW, Butler TM, Armitage JN, Aho T, Riddick ACP, Gnanapragasam V, Welsh SJ, Meyer KB, Warren AY, Tran MGB, Stewart GD, Cortés-Ciriano I, Behjati S, Clatworthy MR, Campbell PJ, Teichmann SA, Mitchell TJ. Li R, et al. Cancer Cell. 2022 Dec 12;40(12):1583-1599.e10. doi: 10.1016/j.ccell.2022.11.001. Epub 2022 Nov 23. Cancer Cell. 2022. PMID: 36423636 Free PMC article.
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To understand these dependencies within the wider microenvironment, we studied over 270,000 single-cell transcriptomes and 100 microdissected whole ex …
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To underst …
Role of Salivary Biomarkers in Oral Cancer Detection.
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Khurshid Z, et al. Adv Clin Chem. 2018;86:23-70. doi: 10.1016/bs.acc.2018.05.002. Epub 2018 Jul 23. Adv Clin Chem. 2018. PMID: 30144841 Review.
Oral cancers are the sixth most frequent cancer with a high mortality rate. Oral squamous cell carcinoma accounts for more than 90% of all oral cancers. Standard methods used to detect oral cancers remain comprehensive clinical examination, expensive b …
Oral cancers are the sixth most frequent cancer with a high mortality rate. Oral squamous cell carcinoma accounts for more tha …
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y. Khan M, et al. Front Immunol. 2022 Dec 20;13:1062225. doi: 10.3389/fimmu.2022.1062225. eCollection 2022. Front Immunol. 2022. PMID: 36605187 Free PMC article.
METHODS: Utilizing the data available in The Cancer Genome Atlas (TCGA), pyroptosis-related genes' (PRGs) expression, genomic aberrations, and clinical significance were systematically analyzed in pan-cancer. ...For example, methylation of PRGs in lower grade glioma …
METHODS: Utilizing the data available in The Cancer Genome Atlas (TCGA), pyroptosis-related genes' (PRGs) expression, genomic aberrat …
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer.
Eum HH, Kwon M, Ryu D, Jo A, Chung W, Kim N, Hong Y, Son DS, Kim ST, Lee J, Lee HO, Park WY. Eum HH, et al. Exp Mol Med. 2020 Dec;52(12):1976-1988. doi: 10.1038/s12276-020-00538-y. Epub 2020 Dec 4. Exp Mol Med. 2020. PMID: 33277616 Free PMC article.
Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. ...Dynamic exchange of tumor-promoting signals, including the CCL3-CCR1 or IL1B-IL1R2 interactions, suggests macrophage recruitment and anti-inflammatory …
Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. ...Dynamic exchange …
IL-1beta Is an Androgen-Responsive Target in Macrophages for Immunotherapy of Prostate Cancer.
Wang D, Cheng C, Chen X, Wang J, Liu K, Jing N, Xu P, Xi X, Sun Y, Ji Z, Zhao H, He Y, Zhang K, Du X, Dong B, Fang Y, Zhang P, Qian X, Xue W, Gao WQ, Zhu HH. Wang D, et al. Adv Sci (Weinh). 2023 Jun;10(17):e2206889. doi: 10.1002/advs.202206889. Epub 2023 Apr 24. Adv Sci (Weinh). 2023. PMID: 37092583 Free PMC article.
On the other hand, immune checkpoint blockade has revolutionized the treatment of certain cancer types, but fails to achieve any benefit in advanced PCa, due to an immune suppressive environment. In this study, it is reported that AR signaling pathway is evidently activate …
On the other hand, immune checkpoint blockade has revolutionized the treatment of certain cancer types, but fails to achieve any bene …
Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis.
Liu G, Sun J, Yang ZF, Zhou C, Zhou PY, Guan RY, Sun BY, Wang ZT, Zhou J, Fan J, Qiu SJ, Yi Y. Liu G, et al. Cell Death Dis. 2021 Mar 11;12(3):260. doi: 10.1038/s41419-021-03545-7. Cell Death Dis. 2021. PMID: 33707417 Free PMC article.
Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis and carcinogenesis via crosstalk with cohabitating stromal/cancer cells. ...
Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotype …
Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
Tulotta C, Lefley DV, Freeman K, Gregory WM, Hanby AM, Heath PR, Nutter F, Wilkinson JM, Spicer-Hadlington AR, Liu X, Bradbury SMJ, Hambley L, Cookson V, Allocca G, Kruithof de Julio M, Coleman RE, Brown JE, Holen I, Ottewell PD. Tulotta C, et al. Clin Cancer Res. 2019 May 1;25(9):2769-2782. doi: 10.1158/1078-0432.CCR-18-2202. Epub 2019 Jan 22. Clin Cancer Res. 2019. PMID: 30670488 Free article.
Here we show that endogenous production of IL1B by tumor cells drives metastasis and growth in bone. EXPERIMENTAL DESIGN: Tumor/stromal IL1B and IL1 receptor 1 (IL1R1) expression was assessed in patient samples and effects of the IL1R antagonist, Anakinra, or the …
Here we show that endogenous production of IL1B by tumor cells drives metastasis and growth in bone. EXPERIMENTAL DESIGN: Tumor/strom …
Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment.
Habanjar O, Bingula R, Decombat C, Diab-Assaf M, Caldefie-Chezet F, Delort L. Habanjar O, et al. Int J Mol Sci. 2023 Feb 16;24(4):4002. doi: 10.3390/ijms24044002. Int J Mol Sci. 2023. PMID: 36835413 Free PMC article. Review.
They have been extensively researched as immunostimulatory mediators to promote the generation, migration and recruitment of immune cells that contribute to an effective antitumor immune response or pro-tumor microenvironment. Thus, in many cancers such as breast cancer …
They have been extensively researched as immunostimulatory mediators to promote the generation, migration and recruitment of immune cells th …
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity.
Hou J, Hsu JM, Hung MC. Hou J, et al. Mol Cell. 2021 Nov 18;81(22):4579-4590. doi: 10.1016/j.molcel.2021.09.003. Epub 2021 Sep 24. Mol Cell. 2021. PMID: 34562371 Free PMC article. Review.
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen infection. However, cancer cell pyroptosis (CCP) was recently discovered to be activated by distinct molecular mec …
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome signaling triggers immune cell pyroptosis (ICP) as a host defens …
1,650 results