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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 4
1997 9
1998 6
1999 13
2000 11
2001 5
2002 9
2003 8
2004 7
2005 6
2006 4
2007 5
2008 3
2009 4
2010 4
2011 2
2012 5
2013 4
2014 7
2015 1
2016 9
2017 7
2018 8
2019 8
2020 14
2021 5
2022 4
2023 1
2024 3

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161 results

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Page 1
INPPL1 gene mutations in opsismodysplasia.
Fradet A, Fitzgerald J. Fradet A, et al. J Hum Genet. 2017 Feb;62(2):135-140. doi: 10.1038/jhg.2016.119. Epub 2016 Oct 6. J Hum Genet. 2017. PMID: 27708270 Free PMC article. Review.
SHIP2 has been well studied in the area of insulin resistance and obesity but has roles in cancer and other disorders. Recently, it was reported that mutations in INPPL1 cause opsismodysplasia, a rare, autosomal recessive severe skeletal dysplasia. This review focus …
SHIP2 has been well studied in the area of insulin resistance and obesity but has roles in cancer and other disorders. Recently, it w …
Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition.
Wei W, Geer MJ, Guo X, Dolgalev I, Sanjana NE, Neel BG. Wei W, et al. J Exp Med. 2023 May 1;220(5):e20221563. doi: 10.1084/jem.20221563. Epub 2023 Feb 23. J Exp Med. 2023. PMID: 36820830 Free PMC article.
LZTR1 deletion conferred resistance in 12/14 lines, followed by MAP4K5 (8/14), SPRED2/STK40 (6/14), and INPPL1 (5/14). INPPL1, MAP4K5, or LZTR1 deletion reactivated ERK signaling. INPPL1-mediated sensitization to SHP2i required its NPXY motif but not lipid ph …
LZTR1 deletion conferred resistance in 12/14 lines, followed by MAP4K5 (8/14), SPRED2/STK40 (6/14), and INPPL1 (5/14). INPPL1, …
PTEN and SHIP: Impact on lymphatic metastasis in breast cancer.
Li K, Li GD, Sun LY, Li XQ. Li K, et al. J Cancer Res Ther. 2018 Dec;14(Supplement):S937-S941. doi: 10.4103/0973-1482.193894. J Cancer Res Ther. 2018. PMID: 30539826 Free article. Review.
Lymph node metastasis is the most common form of metastasis in breast cancer and a crucial indicator influencing breast cancer treatment results. ...PTEN and SHIP are critical indicators used to detect occurrence, development, invasion, and metastasis of breast c …
Lymph node metastasis is the most common form of metastasis in breast cancer and a crucial indicator influencing breast cancer …
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma.
Zhou YL, Zheng C, Chen YT, Chen XM. Zhou YL, et al. Onco Targets Ther. 2018 Nov 1;11:7725-7731. doi: 10.2147/OTT.S185803. eCollection 2018. Onco Targets Ther. 2018. PMID: 30464521 Free PMC article.
The Cancer Genome Atlas (TCGA) RNA-seq data and our mRNA data were used to analyze and reveal the relationship between INPPL1 and aggressive clinicopathologic characteristics of PTC. ...Meanwhile, LNM was confirmed to be associated with underexpression of INPPL1 …
The Cancer Genome Atlas (TCGA) RNA-seq data and our mRNA data were used to analyze and reveal the relationship between INPPL1 …
PTEN and Other PtdIns(3,4,5)P(3) Lipid Phosphatases in Breast Cancer.
Csolle MP, Ooms LM, Papa A, Mitchell CA. Csolle MP, et al. Int J Mol Sci. 2020 Dec 2;21(23):9189. doi: 10.3390/ijms21239189. Int J Mol Sci. 2020. PMID: 33276499 Free PMC article. Review.
Interestingly, while PTEN is a bona fide tumour suppressor and is frequently mutated/lost in breast cancer, 5-phosphatases such as PIPP, SHIP2 and SYNJ2, have demonstrated more diverse roles in regulating mammary tumourigenesis. Reduced PIPP expression is associated with t …
Interestingly, while PTEN is a bona fide tumour suppressor and is frequently mutated/lost in breast cancer, 5-phosphatases such as PI …
AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kbeta/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K. Dunn S, et al. Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14. Oncogene. 2022. PMID: 36241868 Free PMC article.
Parallel CRISPR screens in 3 PTEN-null breast cancer cell lines identified genes mediating resistance to capivasertib (AKT inhibitor) and AZD8186 (PI3Kbeta inhibitor). ...The Mcl-1i + PI3Kbeta/AKTi combination was effective across a panel of breast cancer cell lines …
Parallel CRISPR screens in 3 PTEN-null breast cancer cell lines identified genes mediating resistance to capivasertib (AKT inhibitor) …
Small molecule targeting of SHIP1 and SHIP2.
Kerr WG, Pedicone C, Dormann S, Pacherille A, Chisholm JD. Kerr WG, et al. Biochem Soc Trans. 2020 Feb 28;48(1):291-300. doi: 10.1042/BST20190775. Biochem Soc Trans. 2020. PMID: 32049315 Review.
The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as inhibitors that simultaneously target both enzymes have provided promising data linking the phosphatase activity of the SHIP enzymes to disorders and disease states tha …
The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as inhibitors that simultaneous …
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma.
Sánchez-Sendra B, Serna E, Navarro L, González-Muñoz JF, Portero J, Ramos A, Murgui A, Monteagudo C. Sánchez-Sendra B, et al. Sci Rep. 2020 Mar 16;10(1):4771. doi: 10.1038/s41598-020-61637-4. Sci Rep. 2020. PMID: 32179834 Free PMC article.
Cutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. ...This study supports INPPL1 as a miR-205 target gene and, therefore, that the involvement of miR-205 …
Cutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved i …
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y. Xu L, et al. J Exp Clin Cancer Res. 2024 Jan 11;43(1):17. doi: 10.1186/s13046-023-02937-1. J Exp Clin Cancer Res. 2024. PMID: 38200519 Free PMC article.
BACKGROUND: Prohibitin 2 (PHB2) exhibits opposite functions of promoting or inhibiting tumour across various cancer types. In this study, we aim to investigate its functions and underlying mechanisms in the context of gastric cancer (GC). ...
BACKGROUND: Prohibitin 2 (PHB2) exhibits opposite functions of promoting or inhibiting tumour across various cancer types. In this st …
Quantitative Expression of Key Cancer Markers in the AS-30D Hepatocarcinoma Model.
Briones-Orta MA, Delgado-Coello B, Gutiérrez-Vidal R, Sosa-Garrocho M, Macías-Silva M, Mas-Oliva J. Briones-Orta MA, et al. Front Oncol. 2021 Oct 19;11:670292. doi: 10.3389/fonc.2021.670292. eCollection 2021. Front Oncol. 2021. PMID: 34737944 Free PMC article.
Hepatocellular carcinoma is one of the cancers with the highest mortality rate worldwide. HCC is often diagnosed when the disease is already in an advanced stage, making the discovery and implementation of biomarkers for the disease a critical aim in cancer research …
Hepatocellular carcinoma is one of the cancers with the highest mortality rate worldwide. HCC is often diagnosed when the disease is …
161 results