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125 results

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Page 1
IPMK modulates hepatic glucose production and insulin signaling.
Jung IR, Anokye-Danso F, Jin S, Ahima RS, Kim SF. Jung IR, et al. J Cell Physiol. 2022 Aug;237(8):3421-3432. doi: 10.1002/jcp.30827. Epub 2022 Jul 13. J Cell Physiol. 2022. PMID: 35822903
IPMK-deficient hepatocytes exhibit decreased insulin-induced activation of Akt-FoxO1 signaling. The expression of messenger RNA levels of phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose 6-phosphatase (G6pc), key enzymes mediating gluconeogenesis, are increased in …
IPMK-deficient hepatocytes exhibit decreased insulin-induced activation of Akt-FoxO1 signaling. The expression of messenger RNA level …
IPMK: A versatile regulator of nuclear signaling events.
Kim E, Beon J, Lee S, Park J, Kim S. Kim E, et al. Adv Biol Regul. 2016 May;61:25-32. doi: 10.1016/j.jbior.2015.11.005. Epub 2015 Dec 2. Adv Biol Regul. 2016. PMID: 26682649 Review.
Inositol-derived metabolites (e.g., phosphoinositides and inositol polyphosphates) are key second messengers that are essential for controlling a wide range of cellular events. Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually …
Inositol-derived metabolites (e.g., phosphoinositides and inositol polyphosphates) are key second messengers that are essential for controll …
IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes.
Jung IR, Ahima RS, Kim SF. Jung IR, et al. bioRxiv [Preprint]. 2023 Apr 26:2023.04.26.538310. doi: 10.1101/2023.04.26.538310. bioRxiv. 2023. Update in: J Cell Biochem. 2023 Nov;124(11):1695-1704. doi: 10.1002/jcb.30478. PMID: 37162825 Free PMC article. Updated. Preprint.
Here, we show that excess FFA decreased IPMK expression, and blockade of IPMK decrease attenuated the FFA-induced suppression of Akt phosphorylation in primary mouse hepatocytes (PMH). Moreover, overexpression of IPMK prevented the FFA-induced suppression of …
Here, we show that excess FFA decreased IPMK expression, and blockade of IPMK decrease attenuated the FFA-induced suppression …
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.
Malabanan MM, Blind RD. Malabanan MM, et al. Biochem Soc Trans. 2016 Feb;44(1):279-85. doi: 10.1042/BST20150225. Biochem Soc Trans. 2016. PMID: 26862216 Free PMC article. Review.
By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a f …
By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be …
miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
Lee H, Kim E, Kim S. Lee H, et al. Biomolecules. 2023 Feb 9;13(2):332. doi: 10.3390/biom13020332. Biomolecules. 2023. PMID: 36830701 Free PMC article.
Analysis of the 3' untranslated region (UTR) of mouse IPMK mRNA revealed a highly conserved binding site for miR-181c. Transfection of miR-181c mimics into RAW 264.7 macrophages led to decreased IPMK 3'UTR-luciferase reporter activity and lowered endogenous IPMK …
Analysis of the 3' untranslated region (UTR) of mouse IPMK mRNA revealed a highly conserved binding site for miR-181c. Transfection o …
IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.
Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, Resnick AC, Snyder SH. Guha P, et al. Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. doi: 10.1016/j.celrep.2019.02.013. Cell Rep. 2019. PMID: 30840891 Free PMC article.
Deletion of IPMK diminishes autophagy in cell lines and mouse liver. Regulation of autophagy by IPMK does not require catalytic activity. Two signaling axes, IPMK-AMPK-Sirt-1 and IPMK-AMPK-ULK1, appear to mediate the influence of IPMK on autopha …
Deletion of IPMK diminishes autophagy in cell lines and mouse liver. Regulation of autophagy by IPMK does not require catalyti …
Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice.
Ahn H, Roh JS, Lee S, Beon J, Lee B, Sohn DH, Kim S. Ahn H, et al. Anim Cells Syst (Seoul). 2021 Jul 12;25(4):219-226. doi: 10.1080/19768354.2021.1952305. eCollection 2021. Anim Cells Syst (Seoul). 2021. PMID: 34408810 Free PMC article.
Both wild-type and IPMK KO mice developed similar RA phenotypes; however, conditional deletion of IPMK in myeloid cells led to elevated arthritis scores during the resolution phase, suggesting that IPMK deficiency in myeloid cells impairs the resolution of in …
Both wild-type and IPMK KO mice developed similar RA phenotypes; however, conditional deletion of IPMK in myeloid cells led to …
Out of Phase: How IPMK Inhibits TFEB.
Ferrari L, Martens S. Ferrari L, et al. Dev Cell. 2020 Dec 7;55(5):517-519. doi: 10.1016/j.devcel.2020.11.005. Dev Cell. 2020. PMID: 33290690 Free article.
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans.
Yang ZL, Chen JN, Lu YY, Lu M, Wan QL, Wu GS, Luo HR. Yang ZL, et al. Cell Calcium. 2021 Jan;93:102327. doi: 10.1016/j.ceca.2020.102327. Epub 2020 Dec 1. Cell Calcium. 2021. PMID: 33316585
The deletion mutant ipmk-1(tm2687) displays a long defecation cycle period and retarded postembryonic growth. ...The expression of IPMK-1 in the intestine was sufficient for the wild-type phenotype. The IP3-kinase activity of IPMK-1 is required for defecation …
The deletion mutant ipmk-1(tm2687) displays a long defecation cycle period and retarded postembryonic growth. ...The expression of …
IPMK and beta-catenin mediate PLC-beta1-dependent signaling in myogenic differentiation.
Ramazzotti G, Billi AM, Manzoli L, Mazzetti C, Ruggeri A, Erneux C, Kim S, Suh PG, Cocco L, Faenza I. Ramazzotti G, et al. Oncotarget. 2016 Dec 20;7(51):84118-84127. doi: 10.18632/oncotarget.11527. Oncotarget. 2016. PMID: 27563828 Free PMC article.
We show that the Inositol Polyphosphate Multikinase (IPMK) is able to promote myogenic differentiation since its overexpression determines the up-regulation of several myogenic markers. Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region …
We show that the Inositol Polyphosphate Multikinase (IPMK) is able to promote myogenic differentiation since its overexpression deter …
125 results