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IPMK: A versatile regulator of nuclear signaling events.
Kim E, Beon J, Lee S, Park J, Kim S. Kim E, et al. Adv Biol Regul. 2016 May;61:25-32. doi: 10.1016/j.jbior.2015.11.005. Epub 2015 Dec 2. Adv Biol Regul. 2016. PMID: 26682649 Review.
A series of recent studies have suggested that IPMK may be a multifunctional regulator in the nucleus of mammalian cells. In this review, we highlight the novel modes of action of IPMK in transcriptional and epigenetic regulation, and discuss its roles in physiology …
A series of recent studies have suggested that IPMK may be a multifunctional regulator in the nucleus of mammalian cells. In this rev …
Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice.
Ahn H, Roh JS, Lee S, Beon J, Lee B, Sohn DH, Kim S. Ahn H, et al. Anim Cells Syst (Seoul). 2021 Jul 12;25(4):219-226. doi: 10.1080/19768354.2021.1952305. eCollection 2021. Anim Cells Syst (Seoul). 2021. PMID: 34408810 Free PMC article.
Both wild-type and IPMK KO mice developed similar RA phenotypes; however, conditional deletion of IPMK in myeloid cells led to elevated arthritis scores during the resolution phase, suggesting that IPMK deficiency in myeloid cells impairs the resolution of in …
Both wild-type and IPMK KO mice developed similar RA phenotypes; however, conditional deletion of IPMK in myeloid cells led to …
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans.
Yang ZL, Chen JN, Lu YY, Lu M, Wan QL, Wu GS, Luo HR. Yang ZL, et al. Cell Calcium. 2021 Jan;93:102327. doi: 10.1016/j.ceca.2020.102327. Epub 2020 Dec 1. Cell Calcium. 2021. PMID: 33316585
The expression of IPMK-1 in the intestine was sufficient for the wild-type phenotype. The IP3-kinase activity of IPMK-1 is required for defecation rhythms and postembryonic development. ...
The expression of IPMK-1 in the intestine was sufficient for the wild-type phenotype. The IP3-kinase activity of IPMK-1 is req …
Out of Phase: How IPMK Inhibits TFEB.
Ferrari L, Martens S. Ferrari L, et al. Dev Cell. 2020 Dec 7;55(5):517-519. doi: 10.1016/j.devcel.2020.11.005. Dev Cell. 2020. PMID: 33290690 Free article.
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.
Malabanan MM, Blind RD. Malabanan MM, et al. Biochem Soc Trans. 2016 Feb;44(1):279-85. doi: 10.1042/BST20150225. Biochem Soc Trans. 2016. PMID: 26862216 Free PMC article. Review.
By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a f …
By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be …
IPMK modulates hepatic glucose production and insulin signaling.
Jung IR, Anokye-Danso F, Jin S, Ahima RS, Kim SF. Jung IR, et al. J Cell Physiol. 2022 Aug;237(8):3421-3432. doi: 10.1002/jcp.30827. Epub 2022 Jul 13. J Cell Physiol. 2022. PMID: 35822903
IPMK-deficient hepatocytes exhibit decreased insulin-induced activation of Akt-FoxO1 signaling. The expression of messenger RNA levels of phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose 6-phosphatase (G6pc), key enzymes mediating gluconeogenesis, are increased in
IPMK-deficient hepatocytes exhibit decreased insulin-induced activation of Akt-FoxO1 signaling. The expression of messenger RNA level
Noncatalytic functions of IPMK are essential for activation of autophagy and liver regeneration.
Guha P, Snyder SH. Guha P, et al. Autophagy. 2019 Aug;15(8):1473-1474. doi: 10.1080/15548627.2019.1615305. Epub 2019 May 21. Autophagy. 2019. PMID: 31066329 Free PMC article.
Two signaling axes, IPMK-AMPK-SIRT1 and IPMK-AMPK-ULK1, appear to mediate the influence of IPMK on autophagy. ...Deletion of Ipmk virtually abolishes lipophagy, promotes liver damage and impairs hepatocyte regeneration. ...
Two signaling axes, IPMK-AMPK-SIRT1 and IPMK-AMPK-ULK1, appear to mediate the influence of IPMK on autophagy. ...Deleti …
IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.
Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, Resnick AC, Snyder SH. Guha P, et al. Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. doi: 10.1016/j.celrep.2019.02.013. Cell Rep. 2019. PMID: 30840891 Free PMC article.
Deletion of IPMK diminishes autophagy in cell lines and mouse liver. Regulation of autophagy by IPMK does not require catalytic activity. Two signaling axes, IPMK-AMPK-Sirt-1 and IPMK-AMPK-ULK1, appear to mediate the influence of IPMK on autopha …
Deletion of IPMK diminishes autophagy in cell lines and mouse liver. Regulation of autophagy by IPMK does not require catalyti …
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival.
Dato S, Crocco P, De Rango F, Iannone F, Maletta R, Bruni AC, Saiardi A, Rose G, Passarino G. Dato S, et al. Mech Ageing Dev. 2021 Apr;195:111439. doi: 10.1016/j.mad.2021.111439. Epub 2021 Jan 23. Mech Ageing Dev. 2021. PMID: 33497757
Several studies reported that genetic variants predisposing to neurodegeneration were at higher frequencies in centenarians than in younger controls, suggesting they might favor also longevity. IP6K3 and IPMK regulate many crucial biological functions by mediating synthesi …
Several studies reported that genetic variants predisposing to neurodegeneration were at higher frequencies in centenarians than in younger …
IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation.
Ramazzotti G, Billi AM, Manzoli L, Mazzetti C, Ruggeri A, Erneux C, Kim S, Suh PG, Cocco L, Faenza I. Ramazzotti G, et al. Oncotarget. 2016 Dec 20;7(51):84118-84127. doi: 10.18632/oncotarget.11527. Oncotarget. 2016. PMID: 27563828 Free PMC article.
Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region targeted by PLC-beta1 and that IPMK-induced promoter activation relies upon c-jun binding to the promoter, as we have shown previously for PLC-beta1. Furthermore, our data shows that …
Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region targeted by PLC-beta1 and that IPMK-induced pr …
99 results