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Page 1
IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.
Li M, Li X, Chen S, Zhang T, Song L, Pei J, Sun G, Guo L. Li M, et al. Oxid Med Cell Longev. 2022 Sep 9;2022:6570879. doi: 10.1155/2022/6570879. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36120598 Free PMC article.
By studying IPO5 expression in esophageal cancer tissues, the mechanism associated with IPO5 improving esophageal cancer development was explored in this study. ...The IPO5 gene-silenced esophageal cancer cell model was constructed by len …
By studying IPO5 expression in esophageal cancer tissues, the mechanism associated with IPO5 improving esophageal ca …
IPO5 promotes malignant progression of esophageal cancer through activating MMP7.
Li XF, Aierken AL, Shen L. Li XF, et al. Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4246-4254. doi: 10.26355/eurrev_202004_21004. Eur Rev Med Pharmacol Sci. 2020. PMID: 32373960 Free article.
OBJECTIVE: Previous studies have found that IPO5 is a cancer-promoting gene. However, the role of IPO5 in esophageal cancer has not been reported. ...Meanwhile, IPO5 expression in esophageal cancer cell lines was also detected using qRT-P …
OBJECTIVE: Previous studies have found that IPO5 is a cancer-promoting gene. However, the role of IPO5 in esophageal …
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, Zheng L, Li X. Zhang W, et al. J Exp Clin Cancer Res. 2019 Jul 9;38(1):296. doi: 10.1186/s13046-019-1290-0. J Exp Clin Cancer Res. 2019. PMID: 31288861 Free PMC article.
Mass spectrometry (MS), CO-IP technology, subcellular fractionation, and immunofluorescence were utilized to investigate the possible mechanisms of CRC. RESULTS: IPO5 was highly expressed and positively correlated with the clinicopathological characteristics of colorectal …
Mass spectrometry (MS), CO-IP technology, subcellular fractionation, and immunofluorescence were utilized to investigate the possible mechan …
Nuclear transport proteins are secreted by cancer cells and identified as potential novel cancer biomarkers.
van der Watt PJ, Okpara MO, Wishart A, Parker MI, Soares NC, Blackburn JM, Leaner VD. van der Watt PJ, et al. Int J Cancer. 2022 Jan 15;150(2):347-361. doi: 10.1002/ijc.33832. Epub 2021 Oct 20. Int J Cancer. 2022. PMID: 34591985 Free article.
To investigate their presence in patient serum, enzyme-linked immunosorbent assays were performed and revealed significantly increased levels of KPNbeta1, CRM1, CAS, IPO5 and TNPO1 in cervical and oesophageal cancer patient serum compared to non-cancer contro …
To investigate their presence in patient serum, enzyme-linked immunosorbent assays were performed and revealed significantly increased level …
Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer.
Horak J, Kubecek O, Siskova A, Honkova K, Chvojkova I, Krupova M, Manethova M, Vodenkova S, García-Mulero S, John S, Cecka F, Vodickova L, Petera J, Filip S, Vymetalkova V. Horak J, et al. Front Oncol. 2023 Apr 27;13:1133598. doi: 10.3389/fonc.2023.1133598. eCollection 2023. Front Oncol. 2023. PMID: 37182133 Free PMC article.
Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles differ between Synchronous (SmCRC) and Metachronous (MmCRC) colorectal cancer. ...Two miRNAs were deregulated between SmCRC and MmCRC, …
Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles d …
The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and Virology.
Patouret R. Patouret R. Chimia (Aarau). 2021 Apr 28;75(4):319-322. doi: 10.2533/chimia.2021.319. Chimia (Aarau). 2021. PMID: 33902802 Free article.
The normal function of IPO5 appears to be disrupted in cancer cells due to aberrant overexpression. IPO5 also demonstrated a pivotal role in viral replication. The constant increasing number of publications shows an interest within the scientific community as …
The normal function of IPO5 appears to be disrupted in cancer cells due to aberrant overexpression. IPO5 also demonstra …
Construction and Validation of Early Warning Model of Lung Cancer Based on Machine Learning: A Retrospective Study.
Ye S, Pan J, Ye Z, Cao Z, Cai X, Zheng H, Ye H. Ye S, et al. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221136724. doi: 10.1177/15330338221136724. Technol Cancer Res Treat. 2022. PMID: 36380607 Free PMC article.
The purpose of this study is to construct and validate an early warning model of lung cancer through machine learning. Methods: The CDKN2A gene expression profile and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database and divided into …
The purpose of this study is to construct and validate an early warning model of lung cancer through machine learning. Methods: The C …
Activin and BMP Signalling in Human Testicular Cancer Cell Lines, and a Role for the Nucleocytoplasmic Transport Protein Importin-5 in Their Crosstalk.
Radhakrishnan K, Luu M, Iaria J, Sutherland JM, McLaughlin EA, Zhu HJ, Loveland KL. Radhakrishnan K, et al. Cells. 2023 Mar 24;12(7):1000. doi: 10.3390/cells12071000. Cells. 2023. PMID: 37048077 Free PMC article.
Activin significantly elevated transcripts linked to pluripotency, cancer, TGF-beta, Notch, p53, and Hippo signalling in both lines, whereas BMP4 altered TGF-beta, pluripotency, Hippo and Wnt signalling components. ...IPO5 knockdown in TCam-2 cells using siRNA blunt …
Activin significantly elevated transcripts linked to pluripotency, cancer, TGF-beta, Notch, p53, and Hippo signalling in both lines, …
Soluble syntaxin 3 functions as a transcriptional regulator.
Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Giovannone AJ, et al. J Biol Chem. 2018 Apr 13;293(15):5478-5491. doi: 10.1074/jbc.RA117.000874. Epub 2018 Feb 23. J Biol Chem. 2018. PMID: 29475951 Free PMC article.
Stx3S is differentially expressed in normal human tissues, during epithelial cell polarization, and in breast cancer versus normal breast tissue. Inhibition of endogenous Stx3S expression alters the expression of cancer-associated genes and promotes cell proliferati …
Stx3S is differentially expressed in normal human tissues, during epithelial cell polarization, and in breast cancer versus normal br …
Prognostic Value of Histone Acetyl Transferase 1 (HAT-1) and Inflammatory Signatures in Pancreatic Cancer.
Ortega MA, Jiménez-Álvarez L, Fraile-Martinez O, Garcia-Montero C, Guijarro LG, Pekarek L, Barrena-Blázquez S, Asúnsolo Á, López-González L, Toledo-Lobo MDV, Álvarez-Mon M, Saez MA, Gutiérrez-Calvo A, Díaz-Pedrero R. Ortega MA, et al. Curr Issues Mol Biol. 2024 Apr 25;46(5):3839-3865. doi: 10.3390/cimb46050239. Curr Issues Mol Biol. 2024. PMID: 38785507 Free PMC article.
Pancreatic cancer is a type of gastrointestinal tumor with a growing incidence and mortality worldwide. ...Several studies have shown a correlation between the tissue expression levels of various molecules, measured through immunohistochemistry (IHC), and survival rates in …
Pancreatic cancer is a type of gastrointestinal tumor with a growing incidence and mortality worldwide. ...Several studies have shown …
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