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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 3
1991 1
1992 5
1993 10
1994 14
1995 11
1996 19
1997 25
1998 27
1999 32
2000 26
2001 34
2002 27
2003 25
2004 32
2005 28
2006 26
2007 28
2008 28
2009 35
2010 30
2011 25
2012 31
2013 25
2014 36
2015 36
2016 35
2017 50
2018 42
2019 51
2020 63
2021 61
2022 85
2023 73
2024 37

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1,021 results

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Page 1
SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.
Gao K, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C, Wan X. Gao K, et al. Cell Death Differ. 2023 Feb;30(2):475-487. doi: 10.1038/s41418-022-01097-7. Epub 2022 Dec 8. Cell Death Differ. 2023. PMID: 36481790 Free PMC article.
In contrast, EC-associated SPOP mutants lose their capacity to degrade IRF1 but stabilize IRF1, and upregulate PD-L1 expression. EC-associated SPOP mutations accelerate xenograft tumor growth partially by increasing IRF1 and PD-L1 expression. Together, we ide …
In contrast, EC-associated SPOP mutants lose their capacity to degrade IRF1 but stabilize IRF1, and upregulate PD-L1 expressio …
BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer.
Wang J, Xu Y, Rao X, Zhang R, Tang J, Zhang D, Jie X, Zhu K, Wang X, Xu Y, Zhang S, Dong X, Zhang T, Yang K, Xu S, Meng R, Wu G. Wang J, et al. Clin Transl Med. 2022 Jan;12(1):e718. doi: 10.1002/ctm2.718. Clin Transl Med. 2022. PMID: 35083874 Free PMC article.
BACKGROUND: Chemoradiotherapy-induced PD-L1 upregulation leads to therapeutic resistance and treatment failure. The PD-1/PD-L1 blocking antibodies sensitize cancers to chemoradiotherapy by blocking extracellular PD-1 and PD-L1 binding without affecting the oncogenic functi …
BACKGROUND: Chemoradiotherapy-induced PD-L1 upregulation leads to therapeutic resistance and treatment failure. The PD-1/PD-L1 blocking anti …
Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunity.
Wu Y, Zhou L, Zou Y, Zhang Y, Zhang M, Xu L, Zheng L, He W, Yu K, Li T, Zhang X, Chen Z, Zhang R, Zhou P, Zhang N, Zheng L, Kang T. Wu Y, et al. Nat Cancer. 2023 Mar;4(3):382-400. doi: 10.1038/s43018-023-00522-1. Epub 2023 Mar 9. Nat Cancer. 2023. PMID: 36894639 Free PMC article.
KAT8-IRF1 condensation promotes IRF1 K78 acetylation and binding to the CD247 (PD-L1) promoter and further enriches the transcription apparatus to promote transcription of PD-L1 mRNA. Based on the mechanism of KAT8-IRF1 condensate formation, we identified the …
KAT8-IRF1 condensation promotes IRF1 K78 acetylation and binding to the CD247 (PD-L1) promoter and further enriches the transc …
Inflammasome signaling in colorectal cancer.
Sharma BR, Kanneganti TD. Sharma BR, et al. Transl Res. 2023 Feb;252:45-52. doi: 10.1016/j.trsl.2022.09.002. Epub 2022 Sep 21. Transl Res. 2023. PMID: 36150688 Free PMC article. Review.
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world. ...Inflammasomes can also act as integral components of PANoptosomes, which are multifaceted complexes that integrate components from other cell death pathways and regulate a …
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world. ...Inflammasomes can also act as i …
A neutrophil response linked to tumor control in immunotherapy.
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F, Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder R, Klein AM, Pittet MJ. Gungabeesoon J, et al. Cell. 2023 Mar 30;186(7):1448-1464.e20. doi: 10.1016/j.cell.2023.02.032. Cell. 2023. PMID: 37001504 Free PMC article.
Neutrophils are not homogeneous, however, and could play different roles in cancer therapy. Here, we investigate the role of neutrophils in immunotherapy, leading to tumor control. ...In addition, we found that a therapy-elicited systemic neutrophil response positively cor …
Neutrophils are not homogeneous, however, and could play different roles in cancer therapy. Here, we investigate the role of neutroph …
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.
Karki R, Sharma BR, Lee E, Banoth B, Malireddi RKS, Samir P, Tuladhar S, Mummareddy H, Burton AR, Vogel P, Kanneganti TD. Karki R, et al. JCI Insight. 2020 Jun 18;5(12):e136720. doi: 10.1172/jci.insight.136720. JCI Insight. 2020. PMID: 32554929 Free PMC article.
Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not c …
Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the i …
IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis.
Chen Y, Lin B, Yang S, Huang J. Chen Y, et al. Exp Cell Res. 2023 Oct 1;431(1):113733. doi: 10.1016/j.yexcr.2023.113733. Epub 2023 Jul 29. Exp Cell Res. 2023. PMID: 37517591
IRF1 is a tumor suppressor gene in colon cancer. This study aimed to explore the potential regulation of IRF1 on the ferroptosis of colon cancer and the mechanisms underlying its regulation of GPX4 transcription. ...The role of the IRF1/SPI1-GPX …
IRF1 is a tumor suppressor gene in colon cancer. This study aimed to explore the potential regulation of IRF1 on the fe …
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer.
Zhou P, Shi H, Huang H, Sun X, Yuan S, Chapman NM, Connelly JP, Lim SA, Saravia J, Kc A, Pruett-Miller SM, Chi H. Zhou P, et al. Nature. 2023 Dec;624(7990):154-163. doi: 10.1038/s41586-023-06733-x. Epub 2023 Nov 15. Nature. 2023. PMID: 37968405 Free PMC article.
Mechanistically, TCF-1 and BATF are the targets for IKAROS and ETS1, respectively. Second, the RBPJ-IRF1 axis promoted differentiation of intermediate T(ex) to terminal T(ex) cells. ...Collectively, our study reveals that promoting the exit from quiescence of T(pex) cells …
Mechanistically, TCF-1 and BATF are the targets for IKAROS and ETS1, respectively. Second, the RBPJ-IRF1 axis promoted differentiatio …
IRF1 Inhibits Autophagy-Mediated Proliferation of Colorectal Cancer via Targeting ATG13.
Yuan L, Zhang X, Cheng K, Li L, Guo Z, Zeng L. Yuan L, et al. Cancer Invest. 2022 Jan;40(1):35-45. doi: 10.1080/07357907.2021.1961265. Epub 2021 Aug 17. Cancer Invest. 2022. PMID: 34313498
To determine the roles of IRF1 in colorectal cancer (CRC), we investigated the effects of IRF1 in CRC cells. We found that IRF1 inhibit cell proliferation and tumor growth. Under starvation conditions, IRF1 enhanced apoptosis and reduced autopha …
To determine the roles of IRF1 in colorectal cancer (CRC), we investigated the effects of IRF1 in CRC cells. We found t …
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H. Lv H, et al. Cell Metab. 2021 Jan 5;33(1):110-127.e5. doi: 10.1016/j.cmet.2020.10.021. Epub 2020 Nov 9. Cell Metab. 2021. PMID: 33171124 Free article.
NAD(+) metabolism is implicated in aging and cancer. However, its role in immune checkpoint regulation and immune evasion remains unclear. ...Mechanistically, NAD(+) metabolism maintains activity and expression of methylcytosine dioxygenase Tet1 via alpha-ketoglutarate (al …
NAD(+) metabolism is implicated in aging and cancer. However, its role in immune checkpoint regulation and immune evasion remains unc …
1,021 results