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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 2
1998 1
1999 1
2000 4
2001 6
2002 6
2003 6
2004 10
2005 7
2006 10
2007 14
2008 8
2009 14
2010 18
2011 20
2012 10
2013 11
2014 12
2015 23
2016 23
2017 26
2018 19
2019 18
2020 37
2021 37
2022 30
2023 31
2024 22

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382 results

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Page 1
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ, O'Brien C, De Carvalho DD. Roulois D, et al. Cell. 2015 Aug 27;162(5):961-73. doi: 10.1016/j.cell.2015.07.056. Cell. 2015. PMID: 26317465 Free PMC article.
Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry. This is associated with induction of dsRNAs derived at lea …
Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR ta …
Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity.
Qin Z, Fang X, Sun W, Ma Z, Dai T, Wang S, Zong Z, Huang H, Ru H, Lu H, Yang B, Lin S, Zhou F, Zhang L. Qin Z, et al. Nat Immunol. 2022 Aug;23(8):1193-1207. doi: 10.1038/s41590-022-01269-0. Epub 2022 Jul 25. Nat Immunol. 2022. PMID: 35879450
SIRT1 deficiency resulted in IRF3/IRF7 hyperacetylation in the DBD, which inhibited LLPS and innate immunity, resulting in increased viral load and mortality in mice. By developing a genetic code expansion orthogonal system, we demonstrated the presence of an acetyl moiety …
SIRT1 deficiency resulted in IRF3/IRF7 hyperacetylation in the DBD, which inhibited LLPS and innate immunity, resulting in increased …
Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis.
Xing Y, Chen H, Guo Z, Zhou X. Xing Y, et al. Front Cell Dev Biol. 2022 Feb 17;10:789073. doi: 10.3389/fcell.2022.789073. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35252169 Free PMC article.
Gastric cancer is a major health burden worldwide. Circular RNAs (circRNAs) are a novel family of noncoding RNAs that are involved in multiple types of cancers, including gastric cancer. ...Moreover, in vivo experiments confirmed the potentiation of gastric …
Gastric cancer is a major health burden worldwide. Circular RNAs (circRNAs) are a novel family of noncoding RNAs that are involved in …
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
Ling X, Wei S, Ling D, Cao S, Chang R, Wang Q, Yuan Z. Ling X, et al. Cell Mol Biol Lett. 2023 Nov 9;28(1):91. doi: 10.1186/s11658-023-00495-0. Cell Mol Biol Lett. 2023. PMID: 37946128 Free PMC article.
It was then found that Srg3 can be transcriptionally activated by interferon regulatory factor 7 (Irf7), and specific inhibition of Irf7 significantly improved the symptoms of ALI. CONCLUSIONS: Irf7 transcriptionally activates the expression of Srg3, which ca …
It was then found that Srg3 can be transcriptionally activated by interferon regulatory factor 7 (Irf7), and specific inhibition of …
Interferon regulatory factor 7 in inflammation, cancer and infection.
Qing F, Liu Z. Qing F, et al. Front Immunol. 2023 May 12;14:1190841. doi: 10.3389/fimmu.2023.1190841. eCollection 2023. Front Immunol. 2023. PMID: 37251373 Free PMC article. Review.
Activation of IRF7 inhibits various viral and bacterial infections and suppresses the growth and metastasis of some cancers, but it may also affect the tumor microenvironment and promote the development of other cancers. Here, we summarize recent advances in …
Activation of IRF7 inhibits various viral and bacterial infections and suppresses the growth and metastasis of some cancers, b …
Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8(+) T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.
Li P, Zhou D, Chen D, Cheng Y, Chen Y, Lin Z, Zhang X, Huang Z, Cai J, Huang W, Lin Y, Ke H, Long J, Zou Y, Ye S, Lan P. Li P, et al. J Biomed Sci. 2023 Jun 28;30(1):47. doi: 10.1186/s12929-023-00930-6. J Biomed Sci. 2023. PMID: 37380972 Free PMC article.
RESULTS: The transcriptional and proteomic analysis of the activation and cytotoxicity of CD8(+) T cells in human cancer samples demonstrated that IFI35 expression is correlated with increased CD8(+) T cell infiltration and predicted a better outcome in colorectal cance …
RESULTS: The transcriptional and proteomic analysis of the activation and cytotoxicity of CD8(+) T cells in human cancer samples demo …
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.
Lan Q, Peyvandi S, Duffey N, Huang YT, Barras D, Held W, Richard F, Delorenzi M, Sotiriou C, Desmedt C, Lorusso G, Rüegg C. Lan Q, et al. Oncogene. 2019 Apr;38(15):2814-2829. doi: 10.1038/s41388-018-0624-2. Epub 2018 Dec 13. Oncogene. 2019. PMID: 30546090 Free PMC article.
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER(-)) cancers, by reducing rates of recurrences. ...These findings establish chemotherapy-induced immunological dormancy in ER( …
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negat …
IRF7: activation, regulation, modification and function.
Ning S, Pagano JS, Barber GN. Ning S, et al. Genes Immun. 2011 Sep;12(6):399-414. doi: 10.1038/gene.2011.21. Epub 2011 Apr 14. Genes Immun. 2011. PMID: 21490621 Free PMC article. Review.
Moreover, IRF7 is a multifunctional transcription factor, underscored by the fact that it is associated with EBV latency, in which IRF7 is induced as well as activated by the EBV principal oncoprotein latent membrane protein-1 (LMP1). Aberrant production of type I I …
Moreover, IRF7 is a multifunctional transcription factor, underscored by the fact that it is associated with EBV latency, in which …
Self-guarding of MORC3 enables virulence factor-triggered immunity.
Gaidt MM, Morrow A, Fairgrieve MR, Karr JP, Yosef N, Vance RE. Gaidt MM, et al. Nature. 2021 Dec;600(7887):138-142. doi: 10.1038/s41586-021-04054-5. Epub 2021 Nov 10. Nature. 2021. PMID: 34759314 Free PMC article.
Notably, induction of IFN by ICP0 is independent of canonical immune pathways and the IRF3 and IRF7 transcription factors. A CRISPR screen identified the ICP0 target MORC3(4) as an essential negative regulator of IFN. Loss of MORC3 recapitulates the IRF3- and IRF7-i …
Notably, induction of IFN by ICP0 is independent of canonical immune pathways and the IRF3 and IRF7 transcription factors. A CRISPR s …
382 results