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1995 1
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2002 3
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2004 5
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112 results

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Page 1
The Safety and Efficacy of Growth Hormone Secretagogues.
Sigalos JT, Pastuszak AW. Sigalos JT, et al. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004. Epub 2017 Apr 8. Sex Med Rev. 2018. PMID: 28400207 Free PMC article. Review.
AIM: To review the literature on GH secretagogues (GHSs), which include GH-releasing peptides and the orally available small-molecule drug ibutamoren mesylate. METHODS: Review of clinical studies on the safety and efficacy of GHSs in human subjects. ...
AIM: To review the literature on GH secretagogues (GHSs), which include GH-releasing peptides and the orally available small-molecule drug …
Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren.
Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C. Liu H, et al. Nat Commun. 2021 Nov 4;12(1):6410. doi: 10.1038/s41467-021-26735-5. Nat Commun. 2021. PMID: 34737341 Free PMC article.
Here, we report high-resolution cryo-EM structures of the GHSR-G(i) signaling complex with ghrelin and the non-peptide agonist ibutamoren as an investigational new drug. Our structures together with mutagenesis data reveal the molecular basis for the binding of ghrelin and …
Here, we report high-resolution cryo-EM structures of the GHSR-G(i) signaling complex with ghrelin and the non-peptide agonist ibutamoren …
Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Mathew B, Koshy SA. Philip M, et al. Rapid Commun Mass Spectrom. 2022 Sep 30;36(18):e9337. doi: 10.1002/rcm.9337. Rapid Commun Mass Spectrom. 2022. PMID: 35716382
METHODS: This study examines ibutamoren and its metabolites in thoroughbred horses after oral administration. ...The major metabolites can be detected up to 96 hours after a single dose, and ibutamoren can persist for up to 72 hours. CONCLUSIONS: These findings will …
METHODS: This study examines ibutamoren and its metabolites in thoroughbred horses after oral administration. ...The major metabolite …
Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren.
Philip M, Karakka Kal AK, Subhahar MB, Perwad Z, Karatt TK. Philip M, et al. Rapid Commun Mass Spectrom. 2021 Dec 15;35(23):e9201. doi: 10.1002/rcm.9201. Rapid Commun Mass Spectrom. 2021. PMID: 34542924
RESULTS: A total of 32 metabolites for ibutamoren (20 phase I and 12 phase II) were detected. The important findings of the current research are as follows: (1) the growth hormone secretagogue ibutamoren was prone to oxidation, resulting in corresponding hydroxylate …
RESULTS: A total of 32 metabolites for ibutamoren (20 phase I and 12 phase II) were detected. The important findings of the current r …
Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles.
Yoon YS, Jang Y, Hoenen T, Shin H, Lee Y, Kim M. Yoon YS, et al. BMB Rep. 2020 Mar;53(3):166-171. doi: 10.5483/BMBRep.2020.53.3.175. BMB Rep. 2020. PMID: 31964466 Free PMC article.
Based on the chemical structure, the compounds were divided into three groups, diphenylmethane derivatives, promazine derivatives and chemicals with no conserved skeletons. The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects …
Based on the chemical structure, the compounds were divided into three groups, diphenylmethane derivatives, promazine derivatives and chemic …
Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.
Codner E, Cassorla F, Tiulpakov AN, Mericq MV, Avila A, Pescovitz OH, Svensson J, Cerchio K, Krupa D, Gertz BJ, Murphy G. Codner E, et al. Clin Pharmacol Ther. 2001 Jul;70(1):91-8. doi: 10.1067/mcp.2001.116514. Clin Pharmacol Ther. 2001. PMID: 11452249 Clinical Trial.
We evaluated the safety and tolerability and the GH-insulin-like growth factor (IGF) responses to two dosages of oral ibutamoren mesylate given to children with GH deficiency for 7 to 8 days. ...There was no change in serum prolactin, glucose, triiodothyronine, thyroxine, …
We evaluated the safety and tolerability and the GH-insulin-like growth factor (IGF) responses to two dosages of oral ibutamoren mesy …
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Sinha DK, et al. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. Transl Androl Urol. 2020. PMID: 32257855 Free PMC article. Review.
The GHS that will be discussed include sermorelin, growth hormone-releasing peptides (GHRP)-2, GHRP-6, ibutamoren, and ipamorelin. All are potent GH and IGF-1 stimulators that can significantly improve body composition while ameliorating specific hypogonadal symptoms inclu …
The GHS that will be discussed include sermorelin, growth hormone-releasing peptides (GHRP)-2, GHRP-6, ibutamoren, and ipamorelin. Al …
112 results