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Year Number of Results
2009 1
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2012 7
2013 6
2014 9
2015 9
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2018 9
2019 6
2020 3
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2022 4
2023 3
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66 results

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Page 1
The Combination of Icotinib Hydrochloride and Fluzoparib Enhances the Radiosensitivity of Biliary Tract Cancer Cells.
Zhu L, Zhu C, Wang X, Liu H, Zhu Y, Sun X. Zhu L, et al. Cancer Manag Res. 2020 Nov 19;12:11833-11844. doi: 10.2147/CMAR.S265327. eCollection 2020. Cancer Manag Res. 2020. PMID: 33239915 Free PMC article.
In this study, we aimed to explore the effect of combination treatment with icotinib hydrochloride (IH) and fluzoparib (FZ) on radiosensitivity and clarify its underlying mechanism in the HCCC-9810 and GBC-SD human BTC cell lines. ...
In this study, we aimed to explore the effect of combination treatment with icotinib hydrochloride (IH) and fluzoparib (FZ) on …
Relationship between icotinib hydrochloride exposure and clinical outcome in Chinese patients with advanced non-small cell lung cancer.
Ni J, Liu DY, Hu B, Li C, Jiang J, Wang HP, Zhang L. Ni J, et al. Cancer. 2015 Sep 1;121 Suppl 17:3146-56. doi: 10.1002/cncr.29568. Cancer. 2015. PMID: 26331821 Free article. Clinical Trial.
BACKGROUND: The current study was conducted to explore the relationship between icotinib hydrochloride exposure and therapeutic effects in Chinese patients with advanced non-small cell lung cancer (NSCLC) who were treated with icotinib hydrochloride. M …
BACKGROUND: The current study was conducted to explore the relationship between icotinib hydrochloride exposure and therapeuti …
Icotinib hydrochloride enhances chemo- and radiosensitivity by inhibiting EGFR signaling and attenuating RAD51 expression and function in Hela S3 cells.
Wang X, Gu Y, Liu H, Shi L, Sun X. Wang X, et al. Onco Targets Ther. 2018 Mar 5;11:1245-1258. doi: 10.2147/OTT.S152613. eCollection 2018. Onco Targets Ther. 2018. PMID: 29551903 Free PMC article.
Hence, the aim of this study was to explore the therapeutic efficacy and underlying mechanism of the sensitization to radiation or cisplatin of icotinib hydrochloride (IH), a high-selective EGFR tyrosine kinase inhibitor (TKI), in the Hela S3 human CC cell line. ...
Hence, the aim of this study was to explore the therapeutic efficacy and underlying mechanism of the sensitization to radiation or cisplatin …
Icotinib hydrochloride enhances the effect of radiotherapy by affecting DNA repair in colorectal cancer cells.
Ma H, Bi J, Liu T, Ke Y, Zhang S, Zhang T. Ma H, et al. Oncol Rep. 2015 Mar;33(3):1161-70. doi: 10.3892/or.2014.3699. Epub 2014 Dec 30. Oncol Rep. 2015. PMID: 25572529
The aim of the present study was to explore the efficacy and mechanism of the radiosensitisation of icotinib hydrochloride (IH), a novel oral epidermal growth factor receptor-tyrosine kinase activity inhibitor, by evaluating the changes in tumour cell double-strand …
The aim of the present study was to explore the efficacy and mechanism of the radiosensitisation of icotinib hydrochloride (IH …
Pharmacokinetics and Safety of Icotinib Hydrochloride Cream in Patients with Mild to Moderate Chronic Plaque Psoriasis: A Randomized Double-Blind Vehicle-Controlled Phase 1 Study.
Liu L, Lou H, Zhou J, Shen Y, Zheng M, Ruan Z. Liu L, et al. Biomed Res Int. 2019 May 2;2019:9072683. doi: 10.1155/2019/9072683. eCollection 2019. Biomed Res Int. 2019. PMID: 31187048 Free PMC article. Clinical Trial.
OBJECTIVE: This phase I study aimed to systematically assess the safety, local tolerability, pharmacokinetics, and preliminary efficacy of topical icotinib hydrochloride cream in patients with mild to moderate plaque psoriasis. ...The TPSS improved for all icotin …
OBJECTIVE: This phase I study aimed to systematically assess the safety, local tolerability, pharmacokinetics, and preliminary efficacy of t …
Efficacy and influence factors of icotinib hydrochloride in treating advanced non-small cell lung cancer.
Ma XH, Tian TD, Liu HM, Li QJ, Gao QL, Li L, Shi B. Ma XH, et al. Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):266-274. Eur Rev Med Pharmacol Sci. 2017. PMID: 28165562 Free article. Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of icotinib hydrochloride in the treatment of patients with advanced non-small cell lung cancer (NSCLC) and discuss the influence factors on efficacy. ...Then, the efficacy of icotinib hydrochloride and th …
OBJECTIVE: To evaluate the efficacy and safety of icotinib hydrochloride in the treatment of patients with advanced non-small …
53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells.
Huang A, Yao J, Liu T, Lin Z, Zhang S, Zhang T, Ma H. Huang A, et al. Int J Radiat Biol. 2018 Apr;94(4):327-334. doi: 10.1080/09553002.2018.1434322. Epub 2018 Feb 9. Int J Radiat Biol. 2018. PMID: 29388453
BACKGROUND: This study aimed to investigate the influence of the expression of P53-binding protein 1 (53BP1), a key component in DNA damage repair pathways, on the radiosensitizing effect of icotinib hydrochloride in colorectal cancer and to elucidate the mechanisms …
BACKGROUND: This study aimed to investigate the influence of the expression of P53-binding protein 1 (53BP1), a key component in DNA damage …
Treating advanced non-small-cell lung cancer in Chinese patients: focus on icotinib.
Liang JL, Ren XC, Lin Q. Liang JL, et al. Onco Targets Ther. 2014 May 16;7:761-70. doi: 10.2147/OTT.S49233. eCollection 2014. Onco Targets Ther. 2014. PMID: 24876785 Free PMC article. Review.
Icotinib hydrochloride is an orally administered small-molecule reversible tyrosine kinase inhibitor that has been independently researched and developed and has independent intellectual property rights in the People's Republic of China. ...The present study present …
Icotinib hydrochloride is an orally administered small-molecule reversible tyrosine kinase inhibitor that has been independent …
Icotinib inhibits EGFR signaling and alleviates psoriasis-like symptoms in animal models.
Tan F, Yang G, Wang Y, Chen H, Yu B, Li H, Guo J, Huang X, Deng Y, Yu P, Ding L. Tan F, et al. Biomed Pharmacother. 2018 Feb;98:399-405. doi: 10.1016/j.biopha.2017.12.073. Epub 2017 Dec 27. Biomed Pharmacother. 2018. PMID: 29276968
To investigate the effects of icotinib hydrochloride and a derivative cream on epidermal growth factor receptor (EGFR) signaling and within animal psoriasis models, respectively. ...Icotinib treatment blocked EGFR signaling and reduced HaCaT cell viability as …
To investigate the effects of icotinib hydrochloride and a derivative cream on epidermal growth factor receptor (EGFR) signali …
Influence of wellness education on first-line icotinib hydrochloride patients with stage IV non-small cell lung cancer and their family caregivers.
Yanwei L, Minghui F, Manman Q, Zhuchun Y, Dongying L, Zhanyu P. Yanwei L, et al. Curr Probl Cancer. 2018 May-Jun;42(3):358-366. doi: 10.1016/j.currproblcancer.2018.03.006. Epub 2018 Apr 11. Curr Probl Cancer. 2018. PMID: 29731164 Clinical Trial.
OBJECTIVE: This study aims to examine the effects of wellness education (WE) intervention on the behavioral change, psychological status, performance status on patients with stage IV non-small cell lung cancer (NSCLC) undergoing icotinib hydrochloride treatment and …
OBJECTIVE: This study aims to examine the effects of wellness education (WE) intervention on the behavioral change, psychological status, pe …
66 results