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Year Number of Results
1995 1
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1997 10
1998 6
1999 10
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2001 9
2002 7
2003 10
2004 20
2005 15
2006 25
2007 29
2008 22
2009 17
2010 16
2011 20
2012 22
2013 19
2014 27
2015 28
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2024 16

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566 results

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Page 1
Study on the correlation between DPP9 rs2109069 and IFNAR2 rs2236757 polymorphisms with COVID-19 mortality.
Safari M, Tavakoli R, Aghasadeghi M, Tabatabaee Bafroee AS, Fateh A, Rahimi P. Safari M, et al. Nucleosides Nucleotides Nucleic Acids. 2024 Apr 25:1-16. doi: 10.1080/15257770.2024.2344179. Online ahead of print. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 38660988
To investigate the polymorphisms of IFNAR2 rs2236757 and DPP9 rs2109069, we used the polymerase chain reaction with the restriction fragment length polymorphism assay. The results showed that IFNAR2 rs2236757 A allele is related to the reduced severity of the diseas …
To investigate the polymorphisms of IFNAR2 rs2236757 and DPP9 rs2109069, we used the polymerase chain reaction with the restriction f …
Structural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus.
Chen X, Ke H, Li W, Yin L, Chen W, Chen T, Wu Y, Qiu J, Feng W. Chen X, et al. Int J Biol Macromol. 2024 Apr 20:131721. doi: 10.1016/j.ijbiomac.2024.131721. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38649079
In the structure of the QX006N-Fab/IFNAR1-SD123 complex, QX006N-Fab only recognizes the SD3 subdomain of IFNAR1 by the hydrophobic, hydrogen-bonding and electrostatic interactions. Compared with the structure of the IFN/IFNAR1/IFNAR2 complex, the binding of QX006N-Fab to I …
In the structure of the QX006N-Fab/IFNAR1-SD123 complex, QX006N-Fab only recognizes the SD3 subdomain of IFNAR1 by the hydrophobic, hydrogen …
Genetic variants in ATP2B2 as risk factors for mortality in patients unrelated but not associated with families with severe COVID-19.
López-Bielma MF, Falfán-Valencia R, Fierro-Piña A, Abarca-Rojano E, Córdoba-Lanus E, Fricke-Galindo I, Romero-Villaseñor P, Buendía-Roldán I, Chávez-Galán L, Jaime-Capetillo ME, Pérez-Rubio G. López-Bielma MF, et al. Heliyon. 2024 Apr 9;10(8):e29493. doi: 10.1016/j.heliyon.2024.e29493. eCollection 2024 Apr 30. Heliyon. 2024. PMID: 38628728 Free PMC article.
Methods: Single nucleotide variants (SNVs) in six genes: ATPase plasma membrane Ca(2+) transporting 2 (ATP2B2), transmembrane serine protease 2 (TMPRSS2), dedicator of cytokinesis 2 (DOCK2), (interferon alpha and beta receptor subunit 2) IFNAR2, tumor necrosis factor recep …
Methods: Single nucleotide variants (SNVs) in six genes: ATPase plasma membrane Ca(2+) transporting 2 (ATP2B2), transmembrane serine proteas …
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.
Liu X, Chen H, Ye G, Liu H, Feng C, Chen W, Hu L, Zhou Q, Zhang Z, Li J, Zhang X, He X, Guan Y, Wu Z, Zhao D, Bu Z, Weng C, Huang L. Liu X, et al. PLoS Pathog. 2024 Apr 15;20(4):e1012136. doi: 10.1371/journal.ppat.1012136. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38620034 Free PMC article.
Mechanically, pB318L not only interacted with STING to reduce the translocation of STING from the endoplasmic reticulum to the Golgi apparatus but also interacted with IFN receptors to reduce the interaction of IFNAR1/TYK2 and IFNAR2/JAK1. Of note, ASFV with interruption o …
Mechanically, pB318L not only interacted with STING to reduce the translocation of STING from the endoplasmic reticulum to the Golgi apparat …
Structure-function of type I and III interferons.
de Weerd NA, Kurowska AK, Mendoza JL, Schreiber G. de Weerd NA, et al. Curr Opin Immunol. 2024 Feb;86:102413. doi: 10.1016/j.coi.2024.102413. Epub 2024 Apr 11. Curr Opin Immunol. 2024. PMID: 38608537 Review.
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. ...
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct recept …
Using Mendelian randomization provides genetic insights into potential targets for sepsis treatment.
Xia R, Sun M, Yin J, Zhang X, Li J. Xia R, et al. Sci Rep. 2024 Apr 11;14(1):8467. doi: 10.1038/s41598-024-58457-1. Sci Rep. 2024. PMID: 38605099 Free PMC article.
Furthermore, a range of sensitivity analyses, including MR-Egger intercept tests and Cochran's Q tests, were conducted to evaluate the outcomes of the MR analyses. Three drug targets (PSMA4, IFNAR2, and LY9) exhibited noteworthy MR outcomes in two separate datasets. ...
Furthermore, a range of sensitivity analyses, including MR-Egger intercept tests and Cochran's Q tests, were conducted to evaluate the outco …
Human Chorionic Gonadotrophin (hCG) induces changes in IFN-pathway and Interferon-Stimulated Genes (ISGs) on the bovine endometrium at Day 18 of pregnancy.
Manta MW, da Silva EP, Feltrin SR, Prante AL, Aires KV, de Andrade LG, da Silva AP, Amaral CDS, Wink LM, Portela VM, Antoniazzi AQ. Manta MW, et al. Anim Reprod. 2024 Mar 29;21(1):e20230130. doi: 10.1590/1984-3143-AR2023-0130. eCollection 2024. Anim Reprod. 2024. PMID: 38562608 Free PMC article.
The hCG resulted in greater serum progesterone concentration in the hCG group compared to the C on Day 14. Only the expression of IFNAR2 and STAT1 were upregulated on pregnant cows of the hCG group compared to the C group. ...
The hCG resulted in greater serum progesterone concentration in the hCG group compared to the C on Day 14. Only the expression of IFNAR2 …
Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort.
Skerenova M, Cibulka M, Dankova Z, Holubekova V, Kolkova Z, Lucansky V, Dvorska D, Kapinova A, Krivosova M, Petras M, Baranovicova E, Baranova I, Novakova E, Liptak P, Banovcin P, Bobcakova A, Rosolanka R, Janickova M, Stanclova A, Gaspar L, Caprnda M, Prosecky R, Labudova M, Gabbasov Z, Rodrigo L, Kruzliak P, Lasabova Z, Matakova T, Halasova E. Skerenova M, et al. Adv Med Sci. 2024 Mar 28;69(1):198-207. doi: 10.1016/j.advms.2024.03.007. Online ahead of print. Adv Med Sci. 2024. PMID: 38555007
Significant baseline allelic associations of two DPP9 variants in all tested designs and two IFNAR2 variants in the Omicron pandemic wave were not confirmed by adjusted LR. ...Hospitalized patients' reported comorbidities were not correlated with genetic variants, except f …
Significant baseline allelic associations of two DPP9 variants in all tested designs and two IFNAR2 variants in the Omicron pandemic …
Meta-DHGNN: method for CRS-related cytokines analysis in CAR-T therapy based on meta-learning directed heterogeneous graph neural network.
Wei Z, Zhao C, Zhang M, Xu J, Xu N, Wu S, Xin X, Yu L, Feng W. Wei Z, et al. Brief Bioinform. 2024 Mar 27;25(3):bbae104. doi: 10.1093/bib/bbae104. Brief Bioinform. 2024. PMID: 38546326 Free PMC article.
Furthermore, based on the predicted results, we have explored the multifaceted formation mechanism of CRS in CAR-T therapy from various perspectives and identified several cytokines, such as IFNG (IFN-gamma), IFNA1, IFNB1, IFNA13, IFNA2, IFNAR1, IFNAR2, IFNGR1 and IFNGR2 t …
Furthermore, based on the predicted results, we have explored the multifaceted formation mechanism of CRS in CAR-T therapy from various pers …
Molecular Profile of Variants Potentially Associated with Severe Forms of COVID-19 in Amazonian Indigenous Populations.
Coelho RCC, Martins CLELP, Pastana LF, Rodrigues JCG, Aguiar KEC, Cohen-Paes AN, Gellen LPA, Moraes FCA, Calderaro MCL, de Assunção LA, Monte N, Pereira EEB, Ribeiro-Dos-Santos AM, Ribeiro-do-Santos Â, Rodriguez Burbano RM, de Souza SJ, Guerreiro JF, Assumpção PP, Santos SEBD, Fernandes MR, Santos NPCD. Coelho RCC, et al. Viruses. 2024 Feb 26;16(3):359. doi: 10.3390/v16030359. Viruses. 2024. PMID: 38543725 Free PMC article.
The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to …
The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK …
566 results