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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 2
1987 1
1988 2
1989 1
1990 8
1991 7
1992 12
1993 14
1994 5
1995 7
1996 12
1997 9
1998 8
1999 20
2000 15
2001 15
2002 25
2003 37
2004 38
2005 44
2006 46
2007 52
2008 70
2009 84
2010 103
2011 118
2012 159
2013 201
2014 244
2015 281
2016 327
2017 361
2018 479
2019 476
2020 551
2021 511
2022 317
2023 292
2024 114

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4,497 results

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Page 1
IFNG/IFNG-AS1 expression level balance: implications for autism spectrum disorder.
Fallah H, Sayad A, Ranjbaran F, Talebian F, Ghafouri-Fard S, Taheri M. Fallah H, et al. Metab Brain Dis. 2020 Feb;35(2):327-333. doi: 10.1007/s11011-019-00510-4. Epub 2019 Nov 14. Metab Brain Dis. 2020. PMID: 31728886

The results showed significant up-regulation of IFNG and down-regulation of IFNG-AS1 expression in children with ASD compared to controls (Fold change = 1.5, P < 0.0001; Fold change = -0.143, P = 0.013, respectively). ...Our data reveal a functional disruption in

…
The results showed significant up-regulation of IFNG and down-regulation of IFNG-AS1 expression in children with ASD compared …
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, Wherry EJ, Zhang NR, Ishwaran H, Hellmann MD, Wolchok JD, Kambayashi T, Minn AJ. Benci JL, et al. Cell. 2019 Aug 8;178(4):933-948.e14. doi: 10.1016/j.cell.2019.07.019. Cell. 2019. PMID: 31398344 Free PMC article.
Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade (ICB) is unclear. We show that while inhibiting tumor IFNG signaling decreases interferon-sti …
Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrat …
IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells.
Stein N, Berhani O, Schmiedel D, Duev-Cohen A, Seidel E, Kol I, Tsukerman P, Hecht M, Reches A, Gamliel M, Obeidat A, Charpak-Amikam Y, Yamin R, Mandelboim O. Stein N, et al. iScience. 2019 Jan 25;11:466-473. doi: 10.1016/j.isci.2018.12.034. Epub 2019 Jan 3. iScience. 2019. PMID: 30661002 Free PMC article.
Studies have looked at IFNG-AS1 in T cells, yet IFNG-AS1 function in natural killer cells (NKs), an important source of IFNgamma, remains unknown. ...Using primary human NKs and an NK line with IFNG-AS1 overexpression, we show that IFNG-AS1 is quickly …
Studies have looked at IFNG-AS1 in T cells, yet IFNG-AS1 function in natural killer cells (NKs), an important source of IFNgam …
Autophagy-related IFNG is a prognostic and immunochemotherapeutic biomarker of COAD patients.
Yue T, Cai Y, Zhu J, Liu Y, Chen S, Wang P, Rong L. Yue T, et al. Front Immunol. 2023 Jan 23;14:1064704. doi: 10.3389/fimmu.2023.1064704. eCollection 2023. Front Immunol. 2023. PMID: 36756126 Free PMC article.
For chemotherapy, the autophagy and IFNG were significantly negatively related to the chemosensitivity to cisplatin; IFNG inhibitor glucosamine increased cisplatin chemoresistance while IFNG increased cisplatin chemosensitivity; IFNG could reverse gluc …
For chemotherapy, the autophagy and IFNG were significantly negatively related to the chemosensitivity to cisplatin; IFNG inhi …
Single-cell transcriptomics reveals the interaction between peripheral CD4(+) CTLs and mesencephalic endothelial cells mediated by IFNG in Parkinson's disease.
Yan S, Si Y, Zhou W, Cheng R, Wang P, Wang D, Ding W, Shi W, Jiang Q, Yang F, Yao L. Yan S, et al. Comput Biol Med. 2023 May;158:106801. doi: 10.1016/j.compbiomed.2023.106801. Epub 2023 Mar 21. Comput Biol Med. 2023. PMID: 36989741
The PD-associated Cytotoxic CD4(+) T cells (CD4(+) CTLs) were characterized by a significant increase in proportion as well as enhancement of interferon-gamma (IFNG) response and cell adhesion. Meanwhile, TBX21, IRF1 and NFATC2, identified as the key transcription factors …
The PD-associated Cytotoxic CD4(+) T cells (CD4(+) CTLs) were characterized by a significant increase in proportion as well as enhancement o …
IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study.
Wu SQ, Ding XJ, Yang QL, Wang MG, He JQ. Wu SQ, et al. Eur Rev Med Pharmacol Sci. 2022 Dec;26(23):8777-8787. doi: 10.26355/eurrev_202212_30549. Eur Rev Med Pharmacol Sci. 2022. PMID: 36524496 Free article.
OBJECTIVE: Previous studies suggested that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and its receptor IFNGR1 may be involved in the pathogenesis of tuberculosis (TB). We aimed to examine the association of IFNG gene polymorphisms with TB in t …
OBJECTIVE: Previous studies suggested that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and its receptor IFNGR1 …
CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer.
Huang J, Chen P, Liu K, Liu J, Zhou B, Wu R, Peng Q, Liu ZX, Li C, Kroemer G, Lotze M, Zeh H, Kang R, Tang D. Huang J, et al. Gut. 2021 May;70(5):890-899. doi: 10.1136/gutjnl-2019-320441. Epub 2020 Aug 14. Gut. 2021. PMID: 32816920
OBJECTIVE: Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer …
OBJECTIVE: Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer im …
Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis.
Cui K, Chen Z, Cao Y, Liu S, Ren G, Hu G, Fang D, Wei D, Liu C, Zhu J, Wu C, Zhao K. Cui K, et al. Immunity. 2023 May 9;56(5):944-958.e6. doi: 10.1016/j.immuni.2023.03.006. Epub 2023 Apr 10. Immunity. 2023. PMID: 37040761
While a number of enhancers are described to promote IFN-gamma responses, to the best of our knowledge, no silencers for the Ifng gene have been identified. By examining H3K4me1 histone modification in naive CD4(+) T cells within Ifng locus, we identified a silencer …
While a number of enhancers are described to promote IFN-gamma responses, to the best of our knowledge, no silencers for the Ifng gen …
Regulation of the Ifng locus in the context of T-lineage specification and plasticity.
Balasubramani A, Mukasa R, Hatton RD, Weaver CT. Balasubramani A, et al. Immunol Rev. 2010 Nov;238(1):216-32. doi: 10.1111/j.1600-065X.2010.00961.x. Immunol Rev. 2010. PMID: 20969595 Free PMC article. Review.
Here, we highlight advances in the mapping and functional characterization of cis elements in the Ifng locus that have provided new insights into the control of the chromatin structure and transcriptional activity of this signature T-helper 1 cell gene. We also examine epi …
Here, we highlight advances in the mapping and functional characterization of cis elements in the Ifng locus that have provided new i …
4,497 results