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Page 1
Reversible covalent direct thrombin inhibitors.
Sivaraja M, Pozzi N, Rienzo M, Lin K, Shiau TP, Clemens DM, Igoudin L, Zalicki P, Chang SS, Estiarte MA, Short KM, Williams DC, Datta A, Di Cera E, Kita DB. Sivaraja M, et al. Among authors: igoudin l. PLoS One. 2018 Aug 2;13(8):e0201377. doi: 10.1371/journal.pone.0201377. eCollection 2018. PLoS One. 2018. PMID: 30071045 Free PMC article.
VE-1902-A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis.
Sivaraja M, Clemens DM, Sizikov S, Dash S, Xu C, Rienzo M, Yang B, Ryan M, Chattopadhyay M, Igoudin L, Chang SS, Keutzer S, Zalicki P, Estiarte MA, Shiau TP, Short KM, Williams DC, Datta A, Pozzi N, Di Cera E, Gibson CM, Fox KAA, Kita DB. Sivaraja M, et al. Among authors: igoudin l. Thromb Res. 2020 Jun;190:112-121. doi: 10.1016/j.thromres.2020.04.020. Epub 2020 Apr 19. Thromb Res. 2020. PMID: 32339947 Free PMC article.
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Short KM, Estiarte MA, Pham SM, Williams DC, Igoudin L, Dash S, Sandoval N, Datta A, Pozzi N, Di Cera E, Kita DB. Short KM, et al. Among authors: igoudin l. Eur J Med Chem. 2023 Jan 15;246:114855. doi: 10.1016/j.ejmech.2022.114855. Epub 2022 Oct 27. Eur J Med Chem. 2023. PMID: 36462436
Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease.
Look GC, Jerecic J, Cherbavaz DB, Pray TR, Breach JC, Crosier WJ, Igoudin L, Hironaka CM, Lowe RM, McEntee M, Ruslim-Litrus L, Wu HM, Zhang S, Catalano SM, Goure WF, Summa D, Krafft GA. Look GC, et al. Among authors: igoudin l. Curr Alzheimer Res. 2007 Dec;4(5):562-7. doi: 10.2174/156720507783018271. Curr Alzheimer Res. 2007. PMID: 18220523 Review.