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Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T. Ito Y, et al. Among authors: iguchi hashimoto m. Arthritis Rheum. 2009 Aug;60(8):2294-303. doi: 10.1002/art.24687. Arthritis Rheum. 2009. PMID: 19644886 Free article.
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T. Iguchi-Hashimoto M, et al. PLoS One. 2011;6(10):e27020. doi: 10.1371/journal.pone.0027020. Epub 2011 Oct 27. PLoS One. 2011. PMID: 22046434 Free PMC article.
Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.
Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M, Yukawa N, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Umehara H, Mimori T. Murakami K, et al. Among authors: iguchi hashimoto m. FEBS Lett. 2012 Feb 17;586(4):319-24. doi: 10.1016/j.febslet.2012.01.010. Epub 2012 Jan 17. FEBS Lett. 2012. PMID: 22265692 Free article.