Ikushiro S - Search Results

1

Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.

Zhang H, Patana AS, Mackenzie PI, Ikushiro S, Goldman A, Finel M. Zhang H, et al. Among authors: ikushiro s. Drug Metab Dispos. 2012 Oct;40(10):1935-44. doi: 10.1124/dmd.112.046086. Epub 2012 Jul 10. Drug Metab Dispos. 2012. PMID: 22782802

2

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

Itäaho K, Mackenzie PI, Ikushiro S, Miners JO, Finel M. Itäaho K, et al. Among authors: ikushiro s. Drug Metab Dispos. 2008 Nov;36(11):2307-15. doi: 10.1124/dmd.108.022731. Epub 2008 Aug 21. Drug Metab Dispos. 2008. PMID: 18719240

3

Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.

Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H. Ishii Y, et al. Among authors: ikushiro s. Drug Metab Dispos. 2014 Feb;42(2):229-38. doi: 10.1124/dmd.113.054833. Epub 2013 Nov 19. Drug Metab Dispos. 2014. PMID: 24255116

4

Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.

Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y. Kurita A, et al. Among authors: ikushiro s. J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22. J Pharmacol Exp Ther. 2017. PMID: 28228532 Free article.

5

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.

Miyauchi Y, Kurita A, Yamashita R, Takamatsu T, Ikushiro S, Mackenzie PI, Tanaka Y, Ishii Y. Miyauchi Y, et al. Among authors: ikushiro s. Biochem Biophys Res Commun. 2020 Apr 30;525(2):348-353. doi: 10.1016/j.bbrc.2020.02.075. Epub 2020 Feb 21. Biochem Biophys Res Commun. 2020. PMID: 32093886

6

Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae.

Ikushiro S, Nishikawa M, Masuyama Y, Shouji T, Fujii M, Hamada M, Nakajima N, Finel M, Yasuda K, Kamakura M, Sakaki T. Ikushiro S, et al. Mol Pharm. 2016 Jul 5;13(7):2274-82. doi: 10.1021/acs.molpharmaceut.5b00954. Epub 2016 Jun 8. Mol Pharm. 2016. PMID: 27241161

7

Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.

Ishii Y, Iwanaga M, Nishimura Y, Takeda S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H. Ishii Y, et al. Among authors: ikushiro s. Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76. doi: 10.2133/dmpk.22.367. Drug Metab Pharmacokinet. 2007. PMID: 17965520 Free article.

8

Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism.

Nishimura Y, Maeda S, Ikushiro S, Mackenzie PI, Ishii Y, Yamada H. Nishimura Y, et al. Among authors: ikushiro s. Biochim Biophys Acta. 2007 Nov;1770(11):1557-66. doi: 10.1016/j.bbagen.2007.07.011. Epub 2007 Aug 8. Biochim Biophys Acta. 2007. PMID: 17764847

9

Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

Izukawa T, Nakajima M, Fujiwara R, Yamanaka H, Fukami T, Takamiya M, Aoki Y, Ikushiro S, Sakaki T, Yokoi T. Izukawa T, et al. Among authors: ikushiro s. Drug Metab Dispos. 2009 Aug;37(8):1759-68. doi: 10.1124/dmd.109.027227. Epub 2009 May 13. Drug Metab Dispos. 2009. PMID: 19439486

10

Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.

Okamura K, Ishii Y, Ikushiro S, Mackenzie PI, Yamada H. Okamura K, et al. Among authors: ikushiro s. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1649-56. doi: 10.1016/j.bbrc.2006.05.089. Epub 2006 May 24. Biochem Biophys Res Commun. 2006. PMID: 16737684

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