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Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.
Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L. Čertíková Chábová V, et al. Among authors: imig jd. Kidney Blood Press Res. 2018;43(2):329-349. doi: 10.1159/000487902. Epub 2018 Mar 6. Kidney Blood Press Res. 2018. PMID: 29529602 Free PMC article.
Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats.
Čertíková Chábová V, Kujal P, Vaňourková Z, Škaroupková P, Sadowski J, Kompanowska-Jezierska E, Tesař V, Hammock B, Imig J, Maxová H, Červenka L, Vaněčková I. Čertíková Chábová V, et al. Kidney Blood Press Res. 2019;44(6):1493-1505. doi: 10.1159/000504137. Epub 2019 Nov 26. Kidney Blood Press Res. 2019. PMID: 31770762 Free PMC article.
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats.
Certíková Chábová V, Kramer HJ, Vanecková I, Thumová M, Skaroupková P, Tesar V, Falck JR, Imig JD, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Kidney Blood Press Res. 2007;30(5):335-46. doi: 10.1159/000107710. Epub 2007 Aug 30. Kidney Blood Press Res. 2007. PMID: 17785988
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Clin Sci (Lond). 2010 Feb 23;118(10):617-32. doi: 10.1042/CS20090459. Clin Sci (Lond). 2010. PMID: 20050826 Free PMC article.
Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
Honetschlägerová Z, Husková Z, Vaňourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Červenka L, Kopkan L. Honetschlägerová Z, et al. Among authors: imig jd. J Physiol. 2011 Jan 1;589(Pt 1):207-19. doi: 10.1113/jphysiol.2010.199505. J Physiol. 2011. PMID: 21078594 Free PMC article.
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.
Sporková A, Kopkan L, Varcabová S, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Cervenka L. Sporková A, et al. Among authors: imig jd. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1468-75. doi: 10.1152/ajpregu.00215.2010. Epub 2011 Mar 16. Am J Physiol Regul Integr Comp Physiol. 2011. PMID: 21411763 Free PMC article.
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesař V, Cervenka L. Honetschlägerová Z, et al. Among authors: imig jd. J Hypertens. 2011 Aug;29(8):1590-601. doi: 10.1097/HJH.0b013e328349062f. J Hypertens. 2011. PMID: 21720266 Free PMC article.
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Neckář J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L. Neckář J, et al. Among authors: imig jd. Clin Sci (Lond). 2012 Jun;122(11):513-25. doi: 10.1042/CS20110622. Clin Sci (Lond). 2012. PMID: 22324471 Free PMC article.
Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.
Kopkan L, Husková Z, Sporková A, Varcabová Š, Honetschlägerová Z, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Kramer HJ, Bürgelová M, Vojtíšková A, Kujal P, Vernerová Z, Červenka L. Kopkan L, et al. Among authors: imig jd. Kidney Blood Press Res. 2012;35(6):595-607. doi: 10.1159/000339883. Epub 2012 Aug 29. Kidney Blood Press Res. 2012. PMID: 22948718 Free PMC article.
249 results