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245 results

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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways.
Duan S, Huang W, Liu X, Liu X, Chen N, Xu Q, Hu Y, Song W, Zhou J. Duan S, et al. J Exp Clin Cancer Res. 2018 Dec 5;37(1):304. doi: 10.1186/s13046-018-0980-3. J Exp Clin Cancer Res. 2018. PMID: 30518405 Free PMC article.
A series of in-vivo and in-vitro assays were performed to demonstrate the function of IMPDH2 and its possible mechanisms in CRC. RESULTS: IMPDH2 was upregulated in CRC cells and tissues at both mRNA and protein level. ...On the contrary, knockdown of IMPDH2 a …
A series of in-vivo and in-vitro assays were performed to demonstrate the function of IMPDH2 and its possible mechanisms in CRC. RESU …
Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy.
Liao LX, Song XM, Wang LC, Lv HN, Chen JF, Liu D, Fu G, Zhao MB, Jiang Y, Zeng KW, Tu PF. Liao LX, et al. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5986-E5994. doi: 10.1073/pnas.1706778114. Epub 2017 Jul 3. Proc Natl Acad Sci U S A. 2017. PMID: 28674004 Free PMC article.
Herein, we used a small-molecule probe specifically targeting IMPDH2 and identified Cysteine residue 140 (Cys140) as a selective druggable site. On covalently binding to Cys140, the probe exerts an allosteric regulation to block the catalytic pocket of IMPDH2 and fu …
Herein, we used a small-molecule probe specifically targeting IMPDH2 and identified Cysteine residue 140 (Cys140) as a selective drug …
GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism.
Kofuji S, Sasaki AT. Kofuji S, et al. J Biochem. 2020 Oct 1;168(4):319-328. doi: 10.1093/jb/mvaa085. J Biochem. 2020. PMID: 32702086 Free PMC article. Review.
Using the malignant brain tumour, glioblastoma, as a model, we have demonstrated that one of the rate-limiting enzymes for guanosine triphosphate (GTP) synthesis, inosine monophosphate dehydrogenase-2 (IMPDH2), is increased and IMPDH2 expression is necessary for the …
Using the malignant brain tumour, glioblastoma, as a model, we have demonstrated that one of the rate-limiting enzymes for guanosine triphos …
IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex.
Pua KH, Stiles DT, Sowa ME, Verdine GL. Pua KH, et al. Cell Rep. 2017 Jan 10;18(2):432-442. doi: 10.1016/j.celrep.2016.12.030. Cell Rep. 2017. PMID: 28076787 Free article.
The formation of this ternary complex does not inhibit the enzymatic activity of IMPDH2. Rather, ternary complex formation modulates cell growth through interaction with the cystathionine-beta-synthase (CBS) domain of IMPDH2. We further demonstrate that the SFA comp …
The formation of this ternary complex does not inhibit the enzymatic activity of IMPDH2. Rather, ternary complex formation modulates …
IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder.
Kuukasjärvi A, Landoni JC, Kaukonen J, Juhakoski M, Auranen M, Torkkeli T, Velagapudi V, Suomalainen A. Kuukasjärvi A, et al. Eur J Hum Genet. 2021 Dec;29(12):1833-1837. doi: 10.1038/s41431-021-00939-1. Epub 2021 Jul 26. Eur J Hum Genet. 2021. PMID: 34305140 Free PMC article.
We show that the defect results in degradation of the gene product, causing IMPDH2 deficiency in patient cells. IMPDH2 is the first and rate-limiting enzyme in the de novo biosynthesis of guanine nucleotides, a dopamine synthetic pathway previously linked to childho …
We show that the defect results in degradation of the gene product, causing IMPDH2 deficiency in patient cells. IMPDH2 is the …
IMPDH2 promotes cell proliferation and epithelial-mesenchymal transition of non-small cell lung cancer by activating the Wnt/beta-catenin signaling pathway.
Xu H, Ma H, Zha L, Li Q, Yang G, Pan H, Fei X, Xu X, Xing C, Zhang L. Xu H, et al. Oncol Lett. 2020 Nov;20(5):219. doi: 10.3892/ol.2020.12082. Epub 2020 Sep 9. Oncol Lett. 2020. PMID: 32963625 Free PMC article.
The results of the present study revealed that the expression levels of IMPDH2 were significantly upregulated in NSCLC tissues. Furthermore, the genetic knockdown of IMPDH2 significantly hindered the proliferation, apoptosis, invasion, migration and epithelial-mesen …
The results of the present study revealed that the expression levels of IMPDH2 were significantly upregulated in NSCLC tissues. Furth …
Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.
He X, Cui J, Ma H, Abuduaini N, Huang Y, Tang L, Wang W, Zhang Y, Wang Y, Lu W, Feng B, Huang J. He X, et al. Biochem Pharmacol. 2023 Dec;218:115868. doi: 10.1016/j.bcp.2023.115868. Epub 2023 Oct 21. Biochem Pharmacol. 2023. PMID: 37871880
Via structure-based virtual screening, we identified berberrubine, a critical ingredient of the medical plant Coptis chinensis, as a novel, selective, and competitive inhibitor of IMPDH2, which demonstrated over 15-fold selectivity to IMPDH2 than IMPDH1. ...Taken to …
Via structure-based virtual screening, we identified berberrubine, a critical ingredient of the medical plant Coptis chinensis, as a novel, …
IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells.
Li HX, Meng QP, Liu W, Li YG, Zhang HM, Bao FC, Song LL, Li HJ. Li HX, et al. Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3038-44. Eur Rev Med Pharmacol Sci. 2014. PMID: 25392102 Free article.
MATERIALS AND METHODS: The expression of IMPDH2 was examined in OS cells. Stable cell lines overexpressing IMPDH2 and IMPDH2 knock-down cells were generated using the osteosarcoma cell line. ...Knockdown of IMPDH2 in IMPDH2 rich-expressed Saos-2 …
MATERIALS AND METHODS: The expression of IMPDH2 was examined in OS cells. Stable cell lines overexpressing IMPDH2 and IMPDH …
B7-H3 Associates with IMPDH2 and Regulates Cancer Cell Survival.
Alhamad S, Elmasry Y, Uwagboe I, Chekmeneva E, Sands C, Cooper BW, Camuzeaux S, Salam A, Parsons M. Alhamad S, et al. Cancers (Basel). 2023 Jul 7;15(13):3530. doi: 10.3390/cancers15133530. Cancers (Basel). 2023. PMID: 37444640 Free PMC article.
Here, we present evidence that B7-H3 is associated with one of the key rate-limiting metabolic enzymes IMPDH2, and the localisation of this complex is altered in human lung cancer cells that express high levels of B7-H3. Mechanistically, the IMPDH2:B7-H3 complex pro …
Here, we present evidence that B7-H3 is associated with one of the key rate-limiting metabolic enzymes IMPDH2, and the localisation o …
IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency.
Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernández JA, Walsh K, Ortiz-González XR, Akizu N. Flores-Mendez M, et al. bioRxiv [Preprint]. 2024 Jan 22:2024.01.20.576443. doi: 10.1101/2024.01.20.576443. bioRxiv. 2024. PMID: 38328116 Free PMC article. Preprint.
Remarkably, we found that neurodegeneration resistant regions accumulate micron sized filaments of IMPDH2, the rate limiting enzyme in GTP synthesis. In contrast, IMPDH2 filaments are barely detectable in the hippocampal dentate gyrus, which shows a progressive neur …
Remarkably, we found that neurodegeneration resistant regions accumulate micron sized filaments of IMPDH2, the rate limiting enzyme i …
245 results