Effects of various amino acid 256 mutations on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase function and their role in the cellular adaptive response to thapsigargin.
Yu M, Lin J, Khadeer M, Yeh Y, Inesi G, Hussain A.
Yu M, et al. Among authors: inesi g.
Arch Biochem Biophys. 1999 Feb 15;362(2):225-32. doi: 10.1006/abbi.1998.1049.
Arch Biochem Biophys. 1999.
PMID: 9989931
Since a corresponding Phe is conserved in the Na+, K+-ATPase which is not sensitive to TG, our findings suggest that this amino acid provides stabilization of the stalk segment with respect to the membrane interface, thereby optimizing specific interactions of TG with neighboring …
Since a corresponding Phe is conserved in the Na+, K+-ATPase which is not sensitive to TG, our findings suggest that this amino acid provide …