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1997 2
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404 results

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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. Xu D, et al. Nature. 2020 Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8. Nature. 2020. PMID: 32322062
Phosphorylated PCK1 translocates to the endoplasmic reticulum, where it uses GTP as a phosphate donor to phosphorylate INSIG1 at Ser207 and INSIG2 at Ser151. This phosphorylation reduces the binding of sterols to INSIG1 and INSIG2 and disrupts the interaction betwee …
Phosphorylated PCK1 translocates to the endoplasmic reticulum, where it uses GTP as a phosphate donor to phosphorylate INSIG1 at Ser2 …
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer.
Xiong L, Liu HS, Zhou C, Yang X, Huang L, Jie HQ, Zeng ZW, Zheng XB, Li WX, Liu ZZ, Kang L, Liang ZX. Xiong L, et al. Mol Cancer. 2023 Apr 22;22(1):72. doi: 10.1186/s12943-023-01773-3. Mol Cancer. 2023. PMID: 37087475 Free PMC article.
Mechanistically, circINSIG1 encoded a 121 amino acid protein circINSIG1-121 to promote K48-linked ubiquitination of the critical cholesterol metabolism regulator INSIG1 at lysine 156 and 158 by recruiting CUL5-ASB6 complex, a ubiquitin E3 ligase complex, thereby inducing c …
Mechanistically, circINSIG1 encoded a 121 amino acid protein circINSIG1-121 to promote K48-linked ubiquitination of the critical cholesterol …
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L. Wang Y, et al. Cell Rep. 2022 Nov 29;41(9):111738. doi: 10.1016/j.celrep.2022.111738. Cell Rep. 2022. PMID: 36450259 Free article.
Here, we report that Tim-4 deficiency results in boosted interferon (IFN) signaling and decreased viral load. Mechanistically, Tim-4 disturbs the Insig1-SCAP interaction and promotes SCAP-SREBP2 complex translocation to the Golgi apparatus, eventually leading to the upregu …
Here, we report that Tim-4 deficiency results in boosted interferon (IFN) signaling and decreased viral load. Mechanistically, Tim-4 disturb …
Effect of INSIG1 on the milk fat synthesis of buffalo mammary epithelial cells.
Fan X, Qiu L, Teng X, Zhang Y, Miao Y. Fan X, et al. J Dairy Res. 2020 Aug;87(3):349-355. doi: 10.1017/S0022029920000710. Epub 2020 Sep 10. J Dairy Res. 2020. PMID: 32907640
We hypothesized that insulin-induced gene 1 (INSIG1) affects milk fat synthesis in buffalo. For this reason, the protein abundance of INSIG1 in the mammary tissue of buffalo during the peak period of lactation and dry-off period was evaluated. ...To explore the role …
We hypothesized that insulin-induced gene 1 (INSIG1) affects milk fat synthesis in buffalo. For this reason, the protein abundance of …
Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation.
Xu T, Yu W, Fang H, Wang Z, Chi Z, Guo X, Jiang D, Zhang K, Chen S, Li M, Guo Y, Zhang J, Yang D, Yu Q, Wang D, Zhang X. Xu T, et al. Cell Death Differ. 2022 Aug;29(8):1582-1595. doi: 10.1038/s41418-022-00947-8. Epub 2022 Feb 2. Cell Death Differ. 2022. PMID: 35110683 Free PMC article.
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2alpha-ATF4 axis.
Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R. Watanabe Y, et al. J Biol Chem. 2021 Aug;297(2):100989. doi: 10.1016/j.jbc.2021.100989. Epub 2021 Jul 21. J Biol Chem. 2021. PMID: 34298014 Free PMC article.
In addition, ATF4 upregulation by these oxysterols was attenuated in INSIG1/2-deficient Chinese hamster ovary cells and recovered by either INSIG1 or INSIG2 rescue. Mechanistic studies revealed that the binding of 25HC to INSIG is critical for increased ATF4 protein …
In addition, ATF4 upregulation by these oxysterols was attenuated in INSIG1/2-deficient Chinese hamster ovary cells and recovered by …
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression.
Xu Y, Tao J, Yu X, Wu Y, Chen Y, You K, Zhang J, Getachew A, Pan T, Zhuang Y, Yuan F, Yang F, Lin X, Li YX. Xu Y, et al. JCI Insight. 2021 Oct 8;6(19):e147038. doi: 10.1172/jci.insight.147038. JCI Insight. 2021. PMID: 34622799 Free PMC article.
ASGR1 rescue experiments reduced INSIG1 and restored the SREBP network defect as manifested by improved apolipoprotein B secretion and reduced LDL uptake. ...This finding of an ASGR1/INSIG1/SREBP axis regulating lipid hemostasis may provide multiple potential target …
ASGR1 rescue experiments reduced INSIG1 and restored the SREBP network defect as manifested by improved apolipoprotein B secretion an …
INSIG1 influences obesity-related hypertriglyceridemia in humans.
Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M. Smith EM, et al. J Lipid Res. 2010 Apr;51(4):701-8. doi: 10.1194/jlr.M001404. Epub 2009 Oct 21. J Lipid Res. 2010. PMID: 19965593 Free PMC article.
In our cohort, the INSIG1 promoter SNP rs2721 was associated with TG levels (P = 2 x 10(-3) in 1,560 individuals of the original linkage cohort, P = 8 x 10(-4) in 920 unrelated individuals of the replication cohort, combined P = 9.9 x 10(-6)). Individuals homozygous for th …
In our cohort, the INSIG1 promoter SNP rs2721 was associated with TG levels (P = 2 x 10(-3) in 1,560 individuals of the original link …
404 results