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Inositol hexakisphosphate is required for Integrator function.
Lin MH, Jensen MK, Elrod ND, Huang KL, Welle KA, Wagner EJ, Tong L. Lin MH, et al. Nat Commun. 2022 Sep 30;13(1):5742. doi: 10.1038/s41467-022-33506-3. Nat Commun. 2022. PMID: 36180473 Free PMC article.
IntS11 is the endonuclease for RNA cleavage, as a part of the IntS4-IntS9-IntS11 Integrator cleavage module (ICM). Here we report a cryo-EM structure of the Drosophila ICM, at 2.74 A resolution, revealing stable association of an inositol hexakisphosphate (IP(6)) molecule. …
IntS11 is the endonuclease for RNA cleavage, as a part of the IntS4-IntS9-IntS11 Integrator cleavage module (ICM). Here we report a c …
Structure of the catalytic core of the Integrator complex.
Pfleiderer MM, Galej WP. Pfleiderer MM, et al. Mol Cell. 2021 Mar 18;81(6):1246-1259.e8. doi: 10.1016/j.molcel.2021.01.005. Epub 2021 Feb 5. Mol Cell. 2021. PMID: 33548203 Free PMC article.
Using cryoelectron microscopy (cryo-EM), we determined a 3.5-A-resolution structure of the INTS4/9/11 ternary complex, which constitutes Integrator's catalytic core. Our structure reveals the spatial organization of the catalytic nuclease INTS11, bound to its catalytically …
Using cryoelectron microscopy (cryo-EM), we determined a 3.5-A-resolution structure of the INTS4/9/11 ternary complex, which constitu …
SUMO conjugation regulates the activity of the Integrator complex.
Bragado L, Magalnik M, Mammi P, Romero A, Gaioli N, Pozzi B, Srebrow A. Bragado L, et al. Nucleic Acids Res. 2022 Nov 28;50(21):12444-12461. doi: 10.1093/nar/gkac1055. Nucleic Acids Res. 2022. PMID: 36454007 Free PMC article.
Moreover, while an INTS11 SUMOylation-deficient mutant is still capable of interacting with INTS4 and INTS9, its interaction with other subunits of the complex is affected. ...
Moreover, while an INTS11 SUMOylation-deficient mutant is still capable of interacting with INTS4 and INTS9, its interaction with oth …
The integrator complex is required for integrity of Cajal bodies.
Takata H, Nishijima H, Maeshima K, Shibahara K. Takata H, et al. J Cell Sci. 2012 Jan 1;125(Pt 1):166-75. doi: 10.1242/jcs.090837. Epub 2012 Jan 16. J Cell Sci. 2012. PMID: 22250197
Here, we show that the integrator complex is essential for integrity of the Cajal body. Depletion of INTS4, an integrator complex subunit, abrogated 3'-end processing of snRNA. ...
Here, we show that the integrator complex is essential for integrity of the Cajal body. Depletion of INTS4, an integrator complex sub …
Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.
Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ. Albrecht TR, et al. Nucleic Acids Res. 2018 May 4;46(8):4241-4255. doi: 10.1093/nar/gky100. Nucleic Acids Res. 2018. PMID: 29471365 Free PMC article.
Although INTS4 has no significant homology with Symplekin, it possesses N-terminal HEAT repeats similar to Symplekin but also contains a beta-sheet rich C-terminal region, both of which are important to bind INTS9/11. ...Altogether, these results indicate that INTS4 …
Although INTS4 has no significant homology with Symplekin, it possesses N-terminal HEAT repeats similar to Symplekin but also contain …
Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits.
Fongang B, Wadop YN, Zhu Y, Wagner EJ, Kudlicki A, Rowicka M. Fongang B, et al. Comput Struct Biotechnol J. 2023 Nov 19;21:5686-5697. doi: 10.1016/j.csbj.2023.11.022. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 38074468 Free PMC article.
We then expand our procedure to two complexes whose structures are not well-studied: 1) The heterodimer formed by the Cleavage and Polyadenylation Specificity Factor 100-kD (CPSF100) and 73-kD (CPSF73); 2) The heterotrimer formed by INTS4/INTS9/INTS11. Experimental data su …
We then expand our procedure to two complexes whose structures are not well-studied: 1) The heterodimer formed by the Cleavage and Polyadeny …
Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton.
Lauriat TL, Dracheva S, Kremerskothen J, Duning K, Haroutunian V, Buxbaum JD, Hyde TM, Kleinman JE, McInnes LA. Lauriat TL, et al. Brain Res. 2006 Nov 22;1121(1):1-11. doi: 10.1016/j.brainres.2006.08.099. Epub 2006 Sep 29. Brain Res. 2006. PMID: 17010949
Finally, interacting proteins were identified using a yeast two-hybrid screen to functionally characterize the protein. KIAA0513 interacts with KIBRA, HAX-1, and INTS4, which also interact with proteins involved in neuroplasticity, apoptosis, and cytoskeletal regulation. . …
Finally, interacting proteins were identified using a yeast two-hybrid screen to functionally characterize the protein. KIAA0513 interacts w …