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Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.
Blair WS, Cao J, Jackson L, Jimenez J, Peng Q, Wu H, Isaacson J, Butler SL, Chu A, Graham J, Malfait AM, Tortorella M, Patick AK. Blair WS, et al. Among authors: isaacson j. Antimicrob Agents Chemother. 2007 Oct;51(10):3554-61. doi: 10.1128/AAC.00643-07. Epub 2007 Jul 23. Antimicrob Agents Chemother. 2007. PMID: 17646410 Free PMC article.
HIV capsid is a tractable target for small molecule therapeutic intervention.
Blair WS, Pickford C, Irving SL, Brown DG, Anderson M, Bazin R, Cao J, Ciaramella G, Isaacson J, Jackson L, Hunt R, Kjerrstrom A, Nieman JA, Patick AK, Perros M, Scott AD, Whitby K, Wu H, Butler SL. Blair WS, et al. Among authors: isaacson j. PLoS Pathog. 2010 Dec 9;6(12):e1001220. doi: 10.1371/journal.ppat.1001220. PLoS Pathog. 2010. PMID: 21170360 Free PMC article.
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES. Belmont PJ, et al. Among authors: isaacson j. Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516. Sci Signal. 2014. PMID: 25389372
PSMA-targeted bispecific Fab conjugates that engage T cells.
Patterson JT, Isaacson J, Kerwin L, Atassi G, Duggal R, Bresson D, Zhu T, Zhou H, Fu Y, Kaufmann GF. Patterson JT, et al. Among authors: isaacson j. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5490-5495. doi: 10.1016/j.bmcl.2017.09.065. Epub 2017 Oct 6. Bioorg Med Chem Lett. 2017. PMID: 29126850
Barbenheimer Goes to the Gynecologist.
Isaacson J. Isaacson J. J Am Psychoanal Assoc. 2023 Dec;71(6):1277-1281. doi: 10.1177/00030651241233725. J Am Psychoanal Assoc. 2023. PMID: 38511892 No abstract available.
239 results