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Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.
Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Jensen BL, Palmer LA, Carey RM, Sung SS, Malakauskas SM, Isakson BE, Le TH. Cechova S, et al. Among authors: isakson be. Circulation. 2013 Oct 15;128(16):1770-80. doi: 10.1161/CIRCULATIONAHA.113.003301. Epub 2013 Sep 18. Circulation. 2013. PMID: 24048198
Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.
Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Straub AC, et al. Among authors: isakson be. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2. Arterioscler Thromb Vasc Biol. 2014. PMID: 25278292 Free PMC article.
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. Billaud M, et al. Among authors: isakson be. Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824. Sci Signal. 2015. PMID: 25690012 Free PMC article.
Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).
Keller TC 4th, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE. Keller TC 4th, et al. Among authors: isakson be. Hypertension. 2016 Dec;68(6):1494-1503. doi: 10.1161/HYPERTENSIONAHA.116.08171. Epub 2016 Oct 31. Hypertension. 2016. PMID: 27802421 Free PMC article.
Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis.
DeLalio LJ, Masati E, Mendu S, Ruddiman CA, Yang Y, Johnstone SR, Milstein JA, Keller TCS 4th, Weaver RB, Guagliardo NA, Best AK, Ravichandran KS, Bayliss DA, Sequeira-Lopez MLS, Sonkusare SN, Shu XH, Desai B, Barrett PQ, Le TH, Gomez RA, Isakson BE. DeLalio LJ, et al. Among authors: isakson be. Kidney Int. 2020 Sep;98(3):630-644. doi: 10.1016/j.kint.2020.04.041. Epub 2020 May 21. Kidney Int. 2020. PMID: 32446934 Free PMC article.
156 results