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Identification of human metabolites of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepatic excretion of these metabolites.
Umehara K, Shirai N, Iwatsubo T, Noguchi K, Usui T, Kamimura H. Umehara K, et al. Among authors: iwatsubo t. Drug Metab Dispos. 2009 Aug;37(8):1646-57. doi: 10.1124/dmd.108.026294. Epub 2009 May 13. Drug Metab Dispos. 2009. PMID: 19439489 Clinical Trial.
Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers.
Takusagawa S, van Lier JJ, Suzuki K, Nagata M, Meijer J, Krauwinkel W, Schaddelee M, Sekiguchi M, Miyashita A, Iwatsubo T, van Gelderen M, Usui T. Takusagawa S, et al. Among authors: iwatsubo t. Drug Metab Dispos. 2012 Apr;40(4):815-24. doi: 10.1124/dmd.111.043588. Epub 2012 Jan 23. Drug Metab Dispos. 2012. PMID: 22269146 Clinical Trial.
Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes.
Shiraga T, Yajima K, Teragaki T, Suzuki K, Hashimoto T, Iwatsubo T, Miyashita A, Usui T. Shiraga T, et al. Among authors: iwatsubo t. Biol Pharm Bull. 2012;35(3):413-21. doi: 10.1248/bpb.35.413. Biol Pharm Bull. 2012. PMID: 22382330 Free article.
604 results