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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1992 1
1993 3
1994 16
1995 27
1996 27
1997 48
1998 32
1999 38
2000 47
2001 44
2002 47
2003 52
2004 47
2005 95
2006 174
2007 224
2008 230
2009 261
2010 311
2011 392
2012 357
2013 406
2014 473
2015 485
2016 533
2017 540
2018 592
2019 563
2020 582
2021 649
2022 577
2023 572
2024 292

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7,671 results

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Page 1
The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance.
Park SY, Lee CJ, Choi JH, Kim JH, Kim JW, Kim JY, Nam JS. Park SY, et al. J Exp Clin Cancer Res. 2019 Sep 11;38(1):399. doi: 10.1186/s13046-019-1405-7. J Exp Clin Cancer Res. 2019. PMID: 31511084 Free PMC article.
BACKGROUND: Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresistance survive after RT. ...JAK2/STAT3 signalin …
BACKGROUND: Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal …
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Xu M, Ren L, Fan J, Huang L, Zhou L, Li X, Ye X. Xu M, et al. Life Sci. 2022 Feb 1;290:120266. doi: 10.1016/j.lfs.2021.120266. Epub 2021 Dec 29. Life Sci. 2022. PMID: 34968467
Berberine (BBR), an alkaloid from Chinese herbal medicines, inhibits the proliferation of various cancers. We evaluated the effects and related mechanisms of BBR on gastric cancer. ...Mechanistically, these findings imply that BBR inhibits GC cell proliferation by m …
Berberine (BBR), an alkaloid from Chinese herbal medicines, inhibits the proliferation of various cancers. We evaluated the effects a …
Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.
Perner F, Perner C, Ernst T, Heidel FH. Perner F, et al. Cells. 2019 Aug 8;8(8):854. doi: 10.3390/cells8080854. Cells. 2019. PMID: 31398915 Free PMC article. Review.
The most common mutation within the JAK2 gene is JAK2-V617F that leads to constitutive activation of the kinase and thereby aberrant engagement of downstream signaling pathways. JAK2 mutations can act as central drivers of myeloproliferative neoplasia, a pre- …
The most common mutation within the JAK2 gene is JAK2-V617F that leads to constitutive activation of the kinase and thereby ab …
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.
Liang L, Hui K, Hu C, Wen Y, Yang S, Zhu P, Wang L, Xia Y, Qiao Y, Sun W, Fei J, Chen T, Zhao F, Yang B, Jiang X. Liang L, et al. J Exp Clin Cancer Res. 2019 Feb 12;38(1):71. doi: 10.1186/s13046-019-1093-3. J Exp Clin Cancer Res. 2019. PMID: 30755242 Free PMC article.
Further in vivo studies showed that anlotinib inhibited tumor growth, induced autophagy and suppressed JAK2/STAT3/VEGFA pathway, and CQ enhanced this effect. CONCLUSION: Anlotinib induced apoptosis and protective autophagy in human lung cancer cell lines. Autophagy …
Further in vivo studies showed that anlotinib inhibited tumor growth, induced autophagy and suppressed JAK2/STAT3/VEGFA pathway, and …
Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis.
Wei C, Yang C, Wang S, Shi D, Zhang C, Lin X, Liu Q, Dou R, Xiong B. Wei C, et al. Mol Cancer. 2019 Mar 30;18(1):64. doi: 10.1186/s12943-019-0976-4. Mol Cancer. 2019. PMID: 30927925 Free PMC article.
BACKGROUND: Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumor sites, is considered to be the precursors of tumor …
BACKGROUND: Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metasta …
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH. Jayavelu AK, et al. Nature. 2020 Dec;588(7836):157-163. doi: 10.1038/s41586-020-2968-3. Epub 2020 Nov 25. Nature. 2020. PMID: 33239784
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells(1,2). The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system(3,4) and in haematopoietic cancers(5). ...Therapeutic targeting of YBX1-depende …
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells(1,2). The JAK gene JAK2 is f …
Nuclear JAK2: form and function in cancer.
Qian CJ, Yao J, Si JM. Qian CJ, et al. Anat Rec (Hoboken). 2011 Sep;294(9):1446-59. doi: 10.1002/ar.21443. Epub 2011 Aug 1. Anat Rec (Hoboken). 2011. PMID: 21809458 Free article. Review.
Recent studies demonstrated that JAK2 is a crucial component of signaling pathways operating in the nucleus. ...The aim of this review is intended to summarize the state of our knowledge on nuclear localization of JAK2 and nuclear JAK2 pathways, and to highli …
Recent studies demonstrated that JAK2 is a crucial component of signaling pathways operating in the nucleus. ...The aim of this revie …
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. Chen B, et al. Nat Commun. 2022 Apr 19;13(1):2059. doi: 10.1038/s41467-022-29754-y. Nat Commun. 2022. PMID: 35440133 Free PMC article.
Here, we perform targeted RBP CRISPR/Cas9 screening and identify density regulated re-initiation and release factor (DENR) as a PD-L1 regulator. DENR-depleted cancer cells exhibit reduced PD-L1 expression in vitro and in vivo. ...Mechanistically, DENR antagonizes the trans …
Here, we perform targeted RBP CRISPR/Cas9 screening and identify density regulated re-initiation and release factor (DENR) as a PD-L1 regula …
Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression.
Wagner KU, Rui H. Wagner KU, et al. J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):93-103. doi: 10.1007/s10911-008-9062-z. Epub 2008 Jan 29. J Mammary Gland Biol Neoplasia. 2008. PMID: 18228120 Review.
Following an overview on the function of the Jak2/Stat5 pathway during normal mammary gland development, this review discusses recently published observations on human breast cancers as well as experimental evidence from genetically engineered mice that propose a du …
Following an overview on the function of the Jak2/Stat5 pathway during normal mammary gland development, this review discusses recent …
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G. Hu F, et al. Nat Commun. 2021 Jun 15;12(1):3651. doi: 10.1038/s41467-021-23923-1. Nat Commun. 2021. PMID: 34131122 Free PMC article.
In the present study, we demonstrate that IL-6 activates autophagy through the IL-6/JAK2/BECN1 pathway and promotes chemotherapy resistance in colorectal cancer (CRC). ...Combination treatment with autophagy inhibitors or pharmacological agents targeting the IL-6/ …
In the present study, we demonstrate that IL-6 activates autophagy through the IL-6/JAK2/BECN1 pathway and promotes chemotherapy resi …
7,671 results