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Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.
Pechincha C, Groessl S, Kalis R, de Almeida M, Zanotti A, Wittmann M, Schneider M, de Campos RP, Rieser S, Brandstetter M, Schleiffer A, Müller-Decker K, Helm D, Jabs S, Haselbach D, Lemberg MK, Zuber J, Palm W. Pechincha C, et al. Among authors: jabs s. Science. 2022 Oct 7;378(6615):eabn5637. doi: 10.1126/science.abn5637. Epub 2022 Oct 7. Science. 2022. PMID: 36074822
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Richards CM, et al. Among authors: jabs s. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. Science. 2022. PMID: 36074821 Free PMC article.
Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking.
Schmidtke C, Tiede S, Thelen M, Käkelä R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T. Schmidtke C, et al. Among authors: jabs s. J Biol Chem. 2019 Jun 14;294(24):9592-9604. doi: 10.1074/jbc.RA119.008852. Epub 2019 Apr 30. J Biol Chem. 2019. PMID: 31040178 Free PMC article.
Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles.
Schütz I, Lopez-Hernandez T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, Schmudde M, Rühl E, Graf CM, Haucke V. Schütz I, et al. Among authors: jabs s. J Biol Chem. 2016 Jul 1;291(27):14170-14184. doi: 10.1074/jbc.M115.710947. Epub 2016 May 11. J Biol Chem. 2016. PMID: 27226546 Free PMC article.
3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.
Stellmer F, Keyser B, Burckhardt BC, Koepsell H, Streichert T, Glatzel M, Jabs S, Thiem J, Herdering W, Koeller DM, Goodman SI, Lukacs Z, Ullrich K, Burckhardt G, Braulke T, Mühlhausen C. Stellmer F, et al. Among authors: jabs s. J Mol Med (Berl). 2007 Jul;85(7):763-70. doi: 10.1007/s00109-007-0174-5. Epub 2007 Mar 14. J Mol Med (Berl). 2007. PMID: 17356845
A cation counterflux supports lysosomal acidification.
Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, Grinstein S. Steinberg BE, et al. Among authors: jabs s. J Cell Biol. 2010 Jun 28;189(7):1171-86. doi: 10.1083/jcb.200911083. Epub 2010 Jun 21. J Cell Biol. 2010. PMID: 20566682 Free PMC article.
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