Jacobs SA - Search Results

1

Design of novel FN3 domains with high stability by a consensus sequence approach.

Jacobs SA, Diem MD, Luo J, Teplyakov A, Obmolova G, Malia T, Gilliland GL, O'Neil KT. Jacobs SA, et al. Protein Eng Des Sel. 2012 Mar;25(3):107-17. doi: 10.1093/protein/gzr064. Epub 2012 Jan 12. Protein Eng Des Sel. 2012. PMID: 22240293

2

Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates.

Jacobs SA, Wu SJ, Feng Y, Bethea D, O'Neil KT. Jacobs SA, et al. Pharm Res. 2010 Jan;27(1):65-71. doi: 10.1007/s11095-009-0007-z. Epub 2009 Nov 13. Pharm Res. 2010. PMID: 19911257

3

Structure-based engineering of a monoclonal antibody for improved solubility.

Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y. Wu SJ, et al. Among authors: jacobs sa. Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11. Protein Eng Des Sel. 2010. PMID: 20543007

4

Mechanisms of self-association of a human monoclonal antibody CNTO607.

Bethea D, Wu SJ, Luo J, Hyun L, Lacy ER, Teplyakov A, Jacobs SA, O'Neil KT, Gilliland GL, Feng Y. Bethea D, et al. Among authors: jacobs sa. Protein Eng Des Sel. 2012 Oct;25(10):531-7. doi: 10.1093/protein/gzs047. Epub 2012 Aug 22. Protein Eng Des Sel. 2012. PMID: 22915597

5

C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold.

Teplyakov A, Obmolova G, Malia TJ, Luo J, Jacobs SA, Chan W, Domingo D, Baker A, O'Neil KT, Gilliland GL. Teplyakov A, et al. Among authors: jacobs sa. Proteins. 2014 Jul;82(7):1359-69. doi: 10.1002/prot.24502. Epub 2014 Feb 12. Proteins. 2014. PMID: 24375666

6

N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions.

Luo J, Teplyakov A, Obmolova G, Malia TJ, Chan W, Jacobs SA, O'Neil KT, Gilliland GL. Luo J, et al. Among authors: jacobs sa. Proteins. 2014 Jul;82(7):1527-33. doi: 10.1002/prot.24517. Epub 2014 Feb 18. Proteins. 2014. PMID: 24464739

7

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.

Diem MD, Hyun L, Yi F, Hippensteel R, Kuhar E, Lowenstein C, Swift EJ, O'Neil KT, Jacobs SA. Diem MD, et al. Among authors: jacobs sa. Protein Eng Des Sel. 2014 Oct;27(10):419-29. doi: 10.1093/protein/gzu016. Epub 2014 Apr 30. Protein Eng Des Sel. 2014. PMID: 24786107

8

Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.

Obmolova G, Teplyakov A, Malia TJ, Keough E, Luo J, Sweet R, Jacobs SA, Yi F, Hippensteel R, O'Neil KT, Gilliland GL. Obmolova G, et al. Among authors: jacobs sa. Proteins. 2015 Jun;83(6):1191-7. doi: 10.1002/prot.24815. Epub 2015 May 8. Proteins. 2015. PMID: 25900776 Free PMC article.

9

Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics.

Jacobs SA, Gibbs AC, Conk M, Yi F, Maguire D, Kane C, O'Neil KT. Jacobs SA, et al. Protein Eng Des Sel. 2015 Oct;28(10):385-93. doi: 10.1093/protein/gzv040. Epub 2015 Aug 13. Protein Eng Des Sel. 2015. PMID: 26275855

10

Engineering a targeted delivery platform using Centyrins.

Goldberg SD, Cardoso RM, Lin T, Spinka-Doms T, Klein D, Jacobs SA, Dudkin V, Gilliland G, O'Neil KT. Goldberg SD, et al. Among authors: jacobs sa. Protein Eng Des Sel. 2016 Dec;29(12):563-572. doi: 10.1093/protein/gzw054. Epub 2016 Oct 13. Protein Eng Des Sel. 2016. PMID: 27737926

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