Jacobus DP - Search Results

1

The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug.

Kinyanjui SM, Mberu EK, Winstanley PA, Jacobus DP, Watkins WM. Kinyanjui SM, et al. Among authors: jacobus dp. Am J Trop Med Hyg. 1999 Jun;60(6):943-7. doi: 10.4269/ajtmh.1999.60.943. Am J Trop Med Hyg. 1999. PMID: 10403325

2

PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

Canfield CJ, Milhous WK, Ager AL, Rossan RN, Sweeney TR, Lewis NJ, Jacobus DP. Canfield CJ, et al. Among authors: jacobus dp. Am J Trop Med Hyg. 1993 Jul;49(1):121-6. doi: 10.4269/ajtmh.1993.49.121. Am J Trop Med Hyg. 1993. PMID: 8352384

3

Evolution from double to triple-antimalarial drug combinations.

Shanks GD, Edstein MD, Jacobus D. Shanks GD, et al. Trans R Soc Trop Med Hyg. 2015 Mar;109(3):182-8. doi: 10.1093/trstmh/tru199. Epub 2014 Dec 30. Trans R Soc Trop Med Hyg. 2015. PMID: 25549631 Review.

4

Identification of the optimal third generation antifolate against P. falciparum and P. vivax.

Hunt SY, Detering C, Varani G, Jacobus DP, Schiehser GA, Shieh HM, Nevchas I, Terpinski J, Sibley CH. Hunt SY, et al. Among authors: jacobus dp. Mol Biochem Parasitol. 2005 Dec;144(2):198-205. doi: 10.1016/j.molbiopara.2005.08.014. Epub 2005 Sep 6. Mol Biochem Parasitol. 2005. PMID: 16181688

5

In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.

Shearer TW, Kozar MP, O'Neil MT, Smith PL, Schiehser GA, Jacobus DP, Diaz DS, Yang YS, Milhous WK, Skillman DR. Shearer TW, et al. Among authors: jacobus dp. J Med Chem. 2005 Apr 21;48(8):2805-13. doi: 10.1021/jm049683+. J Med Chem. 2005. PMID: 15828818

6

Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo.

Mui EJ, Jacobus D, Milhous WK, Schiehser G, Hsu H, Roberts CW, Kirisits MJ, McLeod R. Mui EJ, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. doi: 10.1128/AAC.49.8.3463-3467.2005. Antimicrob Agents Chemother. 2005. PMID: 16048961 Free PMC article.

7

Anti-Pneumocystis carinii activity of PS-15, a new biguanide folate antagonist.

Hughes WT, Jacobus DP, Canfield C, Killmar J. Hughes WT, et al. Among authors: jacobus dp. Antimicrob Agents Chemother. 1993 Jul;37(7):1417-9. doi: 10.1128/AAC.37.7.1417. Antimicrob Agents Chemother. 1993. PMID: 8363369 Free PMC article.

8

Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.

Jensen NP, Ager AL, Bliss RA, Canfield CJ, Kotecka BM, Rieckmann KH, Terpinski J, Jacobus DP. Jensen NP, et al. Among authors: jacobus dp. J Med Chem. 2001 Nov 8;44(23):3925-31. doi: 10.1021/jm010089z. J Med Chem. 2001. PMID: 11689078

9

Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.

Diaz DS, Kozar MP, Smith KS, Asher CO, Sousa JC, Schiehser GA, Jacobus DP, Milhous WK, Skillman DR, Shearer TW. Diaz DS, et al. Among authors: jacobus dp. Drug Metab Dispos. 2008 Feb;36(2):380-5. doi: 10.1124/dmd.106.013920. Epub 2007 Nov 15. Drug Metab Dispos. 2008. PMID: 18006651

10

Desensitization to dapsone in HIV-positive patients.

Metroka CE, Lewis NJ, Jacobus DP. Metroka CE, et al. Among authors: jacobus dp. JAMA. 1992 Jan 22-29;267(4):512. doi: 10.1001/jama.267.4.512. JAMA. 1992. PMID: 1530873 No abstract available.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

61 results

Search Page