HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription.
Niu Z, Chen C, Wang S, Lu C, Wu Z, Wang A, Mo J, Zhang J, Han Y, Yuan Y, Zhang Y, Zang Y, He C, Bai X, Tian S, Zhai G, Wu X, Zhang K.
Niu Z, et al.
Nat Commun. 2024 Apr 26;15(1):3561. doi: 10.1038/s41467-024-47900-6.
Nat Commun. 2024.
PMID: 38670996
Using site-specific antibodies, we find that HBO1 may preferentially catalyze histone H3K9la and scaffold proteins including JADE1 and BRPF2 can promote the enzymatic activity for histone Kla. ...
Using site-specific antibodies, we find that HBO1 may preferentially catalyze histone H3K9la and scaffold proteins including JADE1 an …