Jadhav PK - Search Results

1

Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays.

Kuhelj R, Rizzo CJ, Chang CH, Jadhav PK, Towler EM, Korant BD. Kuhelj R, et al. Among authors: jadhav pk. J Biol Chem. 2001 May 18;276(20):16674-82. doi: 10.1074/jbc.M008763200. Epub 2001 Feb 21. J Biol Chem. 2001. PMID: 11278433 Free article.

2

Molecular recognition of cyclic urea HIV-1 protease inhibitors.

Ala PJ, DeLoskey RJ, Huston EE, Jadhav PK, Lam PY, Eyermann CJ, Hodge CN, Schadt MC, Lewandowski FA, Weber PC, McCabe DD, Duke JL, Chang CH. Ala PJ, et al. Among authors: jadhav pk. J Biol Chem. 1998 May 15;273(20):12325-31. doi: 10.1074/jbc.273.20.12325. J Biol Chem. 1998. PMID: 9575185 Free article.

3

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: jadhav pk. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449

4

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.

Hodge CN, Aldrich PE, Bacheler LT, Chang CH, Eyermann CJ, Garber S, Grubb M, Jackson DA, Jadhav PK, Korant B, Lam PY, Maurin MB, Meek JL, Otto MJ, Rayner MM, Reid C, Sharpe TR, Shum L, Winslow DL, Erickson-Viitanen S. Hodge CN, et al. Among authors: jadhav pk. Chem Biol. 1996 Apr;3(4):301-14. doi: 10.1016/s1074-5521(96)90110-6. Chem Biol. 1996. PMID: 8807858

5

Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.

Jadhav PK, Ala P, Woerner FJ, Chang CH, Garber SS, Anton ED, Bacheler LT. Jadhav PK, et al. J Med Chem. 1997 Jan 17;40(2):181-91. doi: 10.1021/jm960586t. J Med Chem. 1997. PMID: 9003516

6

Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.

Jadhav PK, Woerner FJ, Lam PY, Hodge CN, Eyermann CJ, Man HW, Daneker WF, Bacheler LT, Rayner MM, Meek JL, Erickson-Viitanen S, Jackson DA, Calabrese JC, Schadt M, Chang CH. Jadhav PK, et al. J Med Chem. 1998 Apr 23;41(9):1446-55. doi: 10.1021/jm970524i. J Med Chem. 1998. PMID: 9554878

7

Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency.

Han Q, Chang CH, Li R, Ru Y, Jadhav PK, Lam PY. Han Q, et al. Among authors: jadhav pk. J Med Chem. 1998 Jun 4;41(12):2019-28. doi: 10.1021/jm9704199. J Med Chem. 1998. PMID: 9622543

8

Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.

Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH. Ala PJ, et al. Among authors: jadhav pk. Biochemistry. 1998 Oct 27;37(43):15042-9. doi: 10.1021/bi980386e. Biochemistry. 1998. PMID: 9790666

9

Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.

Nugiel DA, Jacobs K, Cornelius L, Chang CH, Jadhav PK, Holler ER, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Logue KA, Gorey-Feret LJ, Lam GN, Erickson-Viitanen S, Seitz SP. Nugiel DA, et al. Among authors: jadhav pk. J Med Chem. 1997 May 9;40(10):1465-74. doi: 10.1021/jm960839i. J Med Chem. 1997. PMID: 9154969

10

Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

Nugiel DA, Jacobs K, Kaltenbach RF, Worley T, Patel M, Meyer DT, Jadhav PK, De Lucca GV, Smyser TE, Klabe RM, Bacheler LT, Rayner MM, Seitz SP. Nugiel DA, et al. Among authors: jadhav pk. J Med Chem. 1996 May 24;39(11):2156-69. doi: 10.1021/jm960083n. J Med Chem. 1996. PMID: 8667359

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