Jaffar M - Search Results

1

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

Phillips RM, Naylor MA, Jaffar M, Doughty SW, Everett SA, Breen AG, Choudry GA, Stratford IJ. Phillips RM, et al. Among authors: jaffar m. J Med Chem. 1999 Oct 7;42(20):4071-80. doi: 10.1021/jm991063z. J Med Chem. 1999. PMID: 10514277

2

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs.

Phillips RM, Jaffar M, Maitland DJ, Loadman PM, Shnyder SD, Steans G, Cooper PA, Race A, Patterson AV, Stratford IJ. Phillips RM, et al. Among authors: jaffar m. Biochem Pharmacol. 2004 Dec 1;68(11):2107-16. doi: 10.1016/j.bcp.2004.08.007. Biochem Pharmacol. 2004. PMID: 15498501

3

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo.

Naylor MA, Jaffar M, Nolan J, Stephens MA, Butler S, Patel KB, Everett SA, Adams GE, Stratford IJ. Naylor MA, et al. Among authors: jaffar m. J Med Chem. 1997 Jul 18;40(15):2335-46. doi: 10.1021/jm9608422. J Med Chem. 1997. PMID: 9240349

4

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.

Jaffar M, Naylor MA, Robertson N, Lockyer SD, Phillips RM, Everett SA, Adams GE, Stratford IJ. Jaffar M, et al. Anticancer Drug Des. 1998 Mar;13(2):105-23. Anticancer Drug Des. 1998. PMID: 9524554

5

Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.

Naylor MA, Swann E, Everett SA, Jaffar M, Nolan J, Robertson N, Lockyer SD, Patel KB, Dennis MF, Stratford MR, Wardman P, Adams GE, Moody CJ, Stratford IJ. Naylor MA, et al. Among authors: jaffar m. J Med Chem. 1998 Jul 16;41(15):2720-31. doi: 10.1021/jm970744w. J Med Chem. 1998. PMID: 9667963

6

Targeting hypoxia with a new generation of indolequinones.

Jaffar M, Naylor MA, Robertson N, Stratford IJ. Jaffar M, et al. Anticancer Drug Des. 1998 Sep;13(6):593-609. Anticancer Drug Des. 1998. PMID: 9755720 Review.

7

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

Ulhaq S, Chinje EC, Naylor MA, Jaffar M, Stratford IJ, Threadgill MD. Ulhaq S, et al. Among authors: jaffar m. Bioorg Med Chem. 1998 Nov;6(11):2139-49. doi: 10.1016/s0968-0896(98)00174-6. Bioorg Med Chem. 1998. PMID: 9881104

8

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones.

Jaffar M, Everett SA, Naylor MA, Moore SG, Ulhaq S, Patel KB, Stratford MR, Nolan J, Wardman P, Stratford IJ. Jaffar M, et al. Bioorg Med Chem Lett. 1999 Jan 4;9(1):113-8. doi: 10.1016/s0960-894x(98)00695-7. Bioorg Med Chem Lett. 1999. PMID: 9990467

9

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.

Saunders MP, Jaffar M, Patterson AV, Nolan J, Naylor MA, Phillips RM, Harris AL, Stratford IJ. Saunders MP, et al. Among authors: jaffar m. Biochem Pharmacol. 2000 Apr 15;59(8):993-6. doi: 10.1016/s0006-2952(99)00405-0. Biochem Pharmacol. 2000. PMID: 10692564

10

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

Murray PE, McNally VA, Lockyer SD, Williams KJ, Stratford IJ, Jaffar M, Freeman S. Murray PE, et al. Among authors: jaffar m. Bioorg Med Chem. 2002 Mar;10(3):525-30. doi: 10.1016/s0968-0896(01)00309-1. Bioorg Med Chem. 2002. PMID: 11814838

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