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Fragment-to-Lead Medicinal Chemistry Publications in 2018.
Erlanson DA, de Esch IJP, Jahnke W, Johnson CN, Mortenson PN. Erlanson DA, et al. Among authors: jahnke w. J Med Chem. 2020 May 14;63(9):4430-4444. doi: 10.1021/acs.jmedchem.9b01581. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31913033
Second-site NMR screening and linker design.
Jahnke W, Flörsheimer A, Blommers MJ, Paris CG, Heim J, Nalin CM, Perez LB. Jahnke W, et al. Curr Top Med Chem. 2003;3(1):69-80. doi: 10.2174/1568026033392778. Curr Top Med Chem. 2003. PMID: 12570778 Review.
Library design for fragment based screening.
Schuffenhauer A, Ruedisser S, Marzinzik AL, Jahnke W, Blommers M, Selzer P, Jacoby E. Schuffenhauer A, et al. Among authors: jahnke w. Curr Top Med Chem. 2005;5(8):751-62. doi: 10.2174/1568026054637700. Curr Top Med Chem. 2005. PMID: 16101415 Review.
Twenty years on: the impact of fragments on drug discovery.
Erlanson DA, Fesik SW, Hubbard RE, Jahnke W, Jhoti H. Erlanson DA, et al. Among authors: jahnke w. Nat Rev Drug Discov. 2016 Sep;15(9):605-619. doi: 10.1038/nrd.2016.109. Epub 2016 Jul 15. Nat Rev Drug Discov. 2016. PMID: 27417849 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2016.
Johnson CN, Erlanson DA, Jahnke W, Mortenson PN, Rees DC. Johnson CN, et al. Among authors: jahnke w. J Med Chem. 2018 Mar 8;61(5):1774-1784. doi: 10.1021/acs.jmedchem.7b01298. Epub 2017 Oct 31. J Med Chem. 2018. PMID: 29087197 Review.
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P. Schoepfer J, et al. Among authors: jahnke w. J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30137981
Fragment-to-Lead Medicinal Chemistry Publications in 2017.
Mortenson PN, Erlanson DA, de Esch IJP, Jahnke W, Johnson CN. Mortenson PN, et al. Among authors: jahnke w. J Med Chem. 2019 Apr 25;62(8):3857-3872. doi: 10.1021/acs.jmedchem.8b01472. Epub 2018 Nov 21. J Med Chem. 2019. PMID: 30462504 Review.
97 results