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An engineered ScCas9 with broad PAM range and high specificity and activity.
Nat Biotechnol. 2020 Oct;38(10):1154-1158. doi: 10.1038/s41587-020-0517-0. Epub 2020 May 11.
Nat Biotechnol. 2020.
PMID: 32393822
Minimal PAM specificity of a highly similar SpCas9 ortholog.
Chatterjee P, Jakimo N, Jacobson JM.
Chatterjee P, et al. Among authors: jakimo n.
Sci Adv. 2018 Oct 24;4(10):eaau0766. doi: 10.1126/sciadv.aau0766. eCollection 2018 Oct.
Sci Adv. 2018.
PMID: 30397647
Free PMC article.
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A Cas9 with PAM recognition for adenine dinucleotides.
Chatterjee P, Lee J, Nip L, Koseki SRT, Tysinger E, Sontheimer EJ, Jacobson JM, Jakimo N.
Chatterjee P, et al. Among authors: jakimo n.
Nat Commun. 2020 May 18;11(1):2474. doi: 10.1038/s41467-020-16117-8.
Nat Commun. 2020.
PMID: 32424114
Free PMC article.
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Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity.
Chatterjee P, Jakimo N, Lee J, Amrani N, Rodríguez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J.
Chatterjee P, et al. Among authors: jakimo n.
Nat Biotechnol. 2020 Oct;38(10):1212. doi: 10.1038/s41587-020-0604-2.
Nat Biotechnol. 2020.
PMID: 32561876
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Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing.
McGaw C, Garrity AJ, Munoz GZ, Haswell JR, Sengupta S, Keston-Smith E, Hunnewell P, Ornstein A, Bose M, Wessells Q, Jakimo N, Yan P, Zhang H, Alfonse LE, Ziblat R, Carte JM, Lu WC, Cerchione D, Hilbert B, Sothiselvam S, Yan WX, Cheng DR, Scott DA, DiTommaso T, Chong S.
McGaw C, et al. Among authors: jakimo n.
Nat Commun. 2022 May 20;13(1):2833. doi: 10.1038/s41467-022-30465-7.
Nat Commun. 2022.
PMID: 35595757
Free PMC article.
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PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P.
Zhao L, et al. Among authors: jakimo n.
Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y.
Nat Commun. 2023.
PMID: 37794046
Free PMC article.
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Evolthon: A community endeavor to evolve lab evolution.
Kaminski Strauss S, Schirman D, Jona G, Brooks AN, Kunjapur AM, Nguyen Ba AN, Flint A, Solt A, Mershin A, Dixit A, Yona AH, Csörgő B, Busby BP, Hennig BP, Pál C, Schraivogel D, Schultz D, Wernick DG, Agashe D, Levi D, Zabezhinsky D, Russ D, Sass E, Tamar E, Herz E, Levy ED, Church GM, Yelin I, Nachman I, Gerst JE, Georgeson JM, Adamala KP, Steinmetz LM, Rübsam M, Ralser M, Klutstein M, Desai MM, Walunjkar N, Yin N, Aharon Hefetz N, Jakimo N, Snitser O, Adini O, Kumar P, Soo Hoo Smith R, Zeidan R, Hazan R, Rak R, Kishony R, Johnson S, Nouriel S, Vonesch SC, Foster S, Dagan T, Wein T, Karydis T, Wannier TM, Stiles T, Olin-Sandoval V, Mueller WF, Bar-On YM, Dahan O, Pilpel Y.
Kaminski Strauss S, et al. Among authors: jakimo n.
PLoS Biol. 2019 Mar 29;17(3):e3000182. doi: 10.1371/journal.pbio.3000182. eCollection 2019 Mar.
PLoS Biol. 2019.
PMID: 30925180
Free PMC article.
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