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Identification and characterization of select oxysterols as ligands for GPR17.
Harrington AW, Liu C, Phillips N, Nepomuceno D, Kuei C, Chang J, Chen W, Sutton SW, O'Malley D, Pham L, Yao X, Sun S, Bonaventure P. Harrington AW, et al. Br J Pharmacol. 2023 Feb;180(4):401-421. doi: 10.1111/bph.15969. Epub 2022 Nov 14. Br J Pharmacol. 2023. PMID: 36214386 Free article.
EXPERIMENTAL APPROACH: Seventy-seven oxysterols were screened in a cell-free [(35) S]GTPgammaS binding assay using membranes from cells expressing GPR17. The positive hits were characterized using adenosine 3',5' cyclic monophosphate (cAMP), inositol monophosphat …
EXPERIMENTAL APPROACH: Seventy-seven oxysterols were screened in a cell-free [(35) S]GTPgammaS binding assay using membranes from cells expr …
Safety and efficacy of apalutamide in Japanese patients with metastatic castration-sensitive prostate cancer receiving androgen deprivation therapy: Final report for the Japanese subpopulation analysis of the randomized, placebo-controlled, phase III TITAN study.
Uemura H, Arai G, Uemura H, Suzuki H, Aoyama J, Hatayama T, Ito M, Lefresne F, McCarthy S, Mundle S, He J, Chi KN. Uemura H, et al. Int J Urol. 2022 Jun;29(6):533-540. doi: 10.1111/iju.14843. Epub 2022 Mar 15. Int J Urol. 2022. PMID: 35293030 Free PMC article. Clinical Trial.
35 results