Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Tkachev V, Vanderbeck A, Perkey E, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS, Maillard I.
Tkachev V, et al. Among authors: lane j.
Sci Transl Med. 2023 Jun 28;15(702):eadd1175. doi: 10.1126/scitranslmed.add1175. Epub 2023 Jun 28.
Sci Transl Med. 2023.
PMID: 37379368
In cross-species investigations, Notch inhibition decreased surface abundance of the gut-homing integrin alpha4beta7 in conventional T cells while preserving alpha4beta7 in regulatory T cells, with findings suggesting increased beta1 competition for alpha4 binding i …
In cross-species investigations, Notch inhibition decreased surface abundance of the gut-homing integrin alpha4beta7 in conventional T …