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1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Mitch CH, Whitesitt C, Brunsting D, Sheardown MJ, Olesen PH, Swedberg MD, Jeppesen L, Sauerberg P. Ward JS, et al. Among authors: jeppesen l. J Med Chem. 1998 Jan 29;41(3):379-92. doi: 10.1021/jm970125n. J Med Chem. 1998. PMID: 9464368
Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
DeLapp N, Wu S, Belagaje R, Johnstone E, Little S, Shannon H, Bymaster F, Calligaro D, Mitch C, Whitesitt C, Ward J, Sheardown M, Fink-Jensen A, Jeppesen L, Thomsen C, Sauerberg P. DeLapp N, et al. Among authors: jeppesen l. Biochem Biophys Res Commun. 1998 Mar 6;244(1):156-60. doi: 10.1006/bbrc.1998.8235. Biochem Biophys Res Commun. 1998. PMID: 9514902
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Bymaster FP, Carter PA, Peters SC, Zhang W, Ward JS, Mitch CH, Calligaro DO, Whitesitt CA, DeLapp N, Shannon HE, Rimvall K, Jeppesen L, Sheardown MJ, Fink-Jensen A, Sauerberg P. Bymaster FP, et al. Among authors: jeppesen l. Brain Res. 1998 Jun 8;795(1-2):179-90. doi: 10.1016/s0006-8993(98)00267-4. Brain Res. 1998. PMID: 9622623
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Sauerberg P, Jeppesen L, Olesen PH, Rasmussen T, Swedberg MD, Sheardown MJ, Fink-Jensen A, Thomsen C, Thøgersen H, Rimvall K, Ward JS, Calligaro DO, DeLapp NW, Bymaster FP, Shannon HE. Sauerberg P, et al. Among authors: jeppesen l. J Med Chem. 1998 Oct 22;41(22):4378-84. doi: 10.1021/jm981048e. J Med Chem. 1998. PMID: 9784113
Potential role of muscarinic receptors in schizophrenia.
Bymaster FP, Shannon HE, Rasmussen K, DeLapp NW, Ward JS, Calligaro DO, Mitch CH, Whitesitt C, Ludvigsen TS, Sheardown M, Swedberg M, Rasmussen T, Olesen PH, Jeppesen L, Sauerberg P, Fink-Jensen A. Bymaster FP, et al. Among authors: jeppesen l. Life Sci. 1999;64(6-7):527-34. doi: 10.1016/s0024-3205(98)00597-9. Life Sci. 1999. PMID: 10069519
The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.
Rasmussen T, Fink-Jensen A, Sauerberg P, Swedberg MD, Thomsen C, Sheardown MJ, Jeppesen L, Calligaro DO, DeLapp NW, Whitesitt C, Ward JS, Shannon HE, Bymaster FP. Rasmussen T, et al. Among authors: jeppesen l. Schizophr Res. 2001 Apr 15;49(1-2):193-201. doi: 10.1016/s0920-9964(00)00129-8. Schizophr Res. 2001. PMID: 11343877
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