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Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Lazarus MB, et al. Among authors: jiang j. Nat Chem Biol. 2012 Dec;8(12):966-8. doi: 10.1038/nchembio.1109. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103939 Free PMC article.
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. Lazarus MB, et al. Among authors: jiang j. Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990. Science. 2013. PMID: 24311690 Free PMC article.
A small molecule that inhibits OGT activity in cells.
Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. Ortiz-Meoz RF, et al. Among authors: jiang j. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. ACS Chem Biol. 2015. PMID: 25751766 Free PMC article.
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