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Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ mobilization.
Jin YR, Cho MR, Ryu CK, Chung JH, Yuk DY, Hong JT, Lee KS, Lee JJ, Lee MY, Lim Y, Yun YP. Jin YR, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):214-9. doi: 10.1124/jpet.104.073718. Epub 2004 Aug 24. J Pharmacol Exp Ther. 2005. PMID: 15328379
Antiplatelet and antithrombotic activities of Korean Red Ginseng.
Yu JY, Jin YR, Lee JJ, Chung JH, Noh JY, You SH, Kim KN, Im JH, Lee JH, Seo JM, Han HJ, Lim Y, Park ES, Kim TJ, Shin KS, Wee JJ, Park JD, Yun YP. Yu JY, et al. Among authors: jin yr. Arch Pharm Res. 2006 Oct;29(10):898-903. doi: 10.1007/BF02973912. Arch Pharm Res. 2006. PMID: 17121186
Antithrombotic and antiplatelet activities of Korean red ginseng extract.
Jin YR, Yu JY, Lee JJ, You SH, Chung JH, Noh JY, Im JH, Han XH, Kim TJ, Shin KS, Wee JJ, Yun YP. Jin YR, et al. Basic Clin Pharmacol Toxicol. 2007 Mar;100(3):170-5. doi: 10.1111/j.1742-7843.2006.00033.x. Basic Clin Pharmacol Toxicol. 2007. PMID: 17309520 Free article.
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