Jinek M - Search Results

1

Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1.

Dumeau CE, Monfort A, Kissling L, Swarts DC, Jinek M, Wutz A. Dumeau CE, et al. Among authors: jinek m. Transgenic Res. 2019 Dec;28(5-6):525-535. doi: 10.1007/s11248-019-00168-9. Epub 2019 Sep 3. Transgenic Res. 2019. PMID: 31482512 Free PMC article.

2

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

Swarts DC, van der Oost J, Jinek M. Swarts DC, et al. Among authors: jinek m. Mol Cell. 2017 Apr 20;66(2):221-233.e4. doi: 10.1016/j.molcel.2017.03.016. Mol Cell. 2017. PMID: 28431230 Free PMC article.

3

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes.

Vlot M, Houkes J, Lochs SJA, Swarts DC, Zheng P, Kunne T, Mohanraju P, Anders C, Jinek M, van der Oost J, Dickman MJ, Brouns SJJ. Vlot M, et al. Among authors: jinek m. Nucleic Acids Res. 2018 Jan 25;46(2):873-885. doi: 10.1093/nar/gkx1264. Nucleic Acids Res. 2018. PMID: 29253268 Free PMC article.

4

Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing.

Swarts DC, Jinek M. Swarts DC, et al. Among authors: jinek m. Wiley Interdiscip Rev RNA. 2018 Sep;9(5):e1481. doi: 10.1002/wrna.1481. Epub 2018 May 22. Wiley Interdiscip Rev RNA. 2018. PMID: 29790280 Review.

5

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.

Swarts DC, Jinek M. Swarts DC, et al. Among authors: jinek m. Mol Cell. 2019 Feb 7;73(3):589-600.e4. doi: 10.1016/j.molcel.2018.11.021. Epub 2019 Jan 10. Mol Cell. 2019. PMID: 30639240 Free PMC article.

6

Preparation and electroporation of Cas12a/Cpf1-guide RNA complexes for introducing large gene deletions in mouse embryonic stem cells.

Kissling L, Monfort A, Swarts DC, Wutz A, Jinek M. Kissling L, et al. Among authors: jinek m. Methods Enzymol. 2019;616:241-263. doi: 10.1016/bs.mie.2018.10.028. Epub 2019 Jan 17. Methods Enzymol. 2019. PMID: 30691645

7

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.

Hegge JW, Swarts DC, Chandradoss SD, Cui TJ, Kneppers J, Jinek M, Joo C, van der Oost J. Hegge JW, et al. Among authors: jinek m. Nucleic Acids Res. 2019 Jun 20;47(11):5809-5821. doi: 10.1093/nar/gkz306. Nucleic Acids Res. 2019. PMID: 31069393 Free PMC article.

8

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.

Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: jinek m. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.

9

Heterologous Expression and Purification of CRISPR-Cas12a/Cpf1.

Mohanraju P, Van Der Oost J, Jinek M, Swarts DC. Mohanraju P, et al. Among authors: jinek m. Bio Protoc. 2018 May 5;8(9):e2842. doi: 10.21769/BioProtoc.2842. eCollection 2018 May 5. Bio Protoc. 2018. PMID: 34286046 Free PMC article.

10

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility.

Schmidheini L, Mathis N, Marquart KF, Rothgangl T, Kissling L, Böck D, Chanez C, Wang JP, Jinek M, Schwank G. Schmidheini L, et al. Among authors: jinek m. Nat Chem Biol. 2024 Mar;20(3):333-343. doi: 10.1038/s41589-023-01427-x. Epub 2023 Sep 21. Nat Chem Biol. 2024. PMID: 37735239

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