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A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
Cohen SIA, Arosio P, Presto J, Kurudenkandy FR, Biverstal H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TPJ, Linse S. Cohen SIA, et al. Among authors: johansson j. Nat Struct Mol Biol. 2015 Mar;22(3):207-213. doi: 10.1038/nsmb.2971. Epub 2015 Feb 16. Nat Struct Mol Biol. 2015. PMID: 25686087 Free PMC article.
Alpha-helix targeting reduces amyloid-beta peptide toxicity.
Nerelius C, Sandegren A, Sargsyan H, Raunak R, Leijonmarck H, Chatterjee U, Fisahn A, Imarisio S, Lomas DA, Crowther DC, Strömberg R, Johansson J. Nerelius C, et al. Among authors: johansson j. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9191-6. doi: 10.1073/pnas.0810364106. Epub 2009 May 20. Proc Natl Acad Sci U S A. 2009. PMID: 19458258 Free PMC article.
1,646 results