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Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS. Zhang W, et al. Among authors: johnson gg. PLoS Pathog. 2017 May 18;13(5):e1006372. doi: 10.1371/journal.ppat.1006372. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28542609 Free PMC article.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. Bailey-Elkin BA, et al. Among authors: johnson gg. J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320088 Free PMC article.
71 results