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Specific increase in potency via structure-based design of a TCR.
Malecek K, Grigoryan A, Zhong S, Gu WJ, Johnson LA, Rosenberg SA, Cardozo T, Krogsgaard M. Malecek K, et al. Among authors: johnson la. J Immunol. 2014 Sep 1;193(5):2587-99. doi: 10.4049/jimmunol.1302344. Epub 2014 Jul 28. J Immunol. 2014. PMID: 25070852 Free PMC article.
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy.
Zhong S, Malecek K, Johnson LA, Yu Z, Vega-Saenz de Miera E, Darvishian F, McGary K, Huang K, Boyer J, Corse E, Shao Y, Rosenberg SA, Restifo NP, Osman I, Krogsgaard M. Zhong S, et al. Among authors: johnson la. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6973-8. doi: 10.1073/pnas.1221609110. Epub 2013 Apr 1. Proc Natl Acad Sci U S A. 2013. PMID: 23576742 Free PMC article.
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.
Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, VanWaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Johnson LA, et al. Blood. 2009 Jul 16;114(3):535-46. doi: 10.1182/blood-2009-03-211714. Epub 2009 May 18. Blood. 2009. PMID: 19451549 Free PMC article. Clinical Trial.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Hinrichs CS, Borman ZA, Gattinoni L, Yu Z, Burns WR, Huang J, Klebanoff CA, Johnson LA, Kerkar SP, Yang S, Muranski P, Palmer DC, Scott CD, Morgan RA, Robbins PF, Rosenberg SA, Restifo NP. Hinrichs CS, et al. Among authors: johnson la. Blood. 2011 Jan 20;117(3):808-14. doi: 10.1182/blood-2010-05-286286. Epub 2010 Oct 22. Blood. 2011. PMID: 20971955 Free PMC article.
696 results