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Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.
Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR. Thompson AA, et al. Among authors: johnson rs. Sci Immunol. 2017 Feb 10;2(8):eaal2861. doi: 10.1126/sciimmunol.aal2861. Sci Immunol. 2017. PMID: 28386604 Free PMC article.
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK. Walmsley SR, et al. Among authors: johnson rs. J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317538 Free PMC article.
Epidermal deletion of HIF-2α stimulates wound closure.
Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. Cowburn AS, et al. Among authors: johnson rs. J Invest Dermatol. 2014 Mar;134(3):801-808. doi: 10.1038/jid.2013.395. Epub 2013 Sep 13. J Invest Dermatol. 2014. PMID: 24037341 Free PMC article.
HIF isoforms in the skin differentially regulate systemic arterial pressure.
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. Cowburn AS, et al. Among authors: johnson rs. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5. doi: 10.1073/pnas.1306942110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101470 Free PMC article.
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR. Thompson AA, et al. Among authors: johnson rs. Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6. Blood. 2014. PMID: 24196071 Free PMC article.
HIF2α-arginase axis is essential for the development of pulmonary hypertension.
Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS. Cowburn AS, et al. Among authors: johnson rs. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432976 Free PMC article.
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O. Siebenmann C, et al. Among authors: johnson rs. Acta Physiol (Oxf). 2017 Jul;220(3):361-369. doi: 10.1111/apha.12825. Epub 2016 Nov 30. Acta Physiol (Oxf). 2017. PMID: 27809413 Free PMC article.
440 results