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Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
Delaney JR, Sutphin GL, Dulken B, Sim S, Kim JR, Robison B, Schleit J, Murakami CJ, Carr D, An EH, Choi E, Chou A, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Johnson S, Raabe C, Suh Y, Zhou Z, Liu X, Kennedy BK, Kaeberlein M. Delaney JR, et al. Aging Cell. 2011 Dec;10(6):1089-91. doi: 10.1111/j.1474-9726.2011.00742.x. Epub 2011 Oct 3. Aging Cell. 2011. PMID: 21902802 Free PMC article.
Molecular mechanisms underlying genotype-dependent responses to dietary restriction.
Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M. Schleit J, et al. Among authors: johnson sc. Aging Cell. 2013 Dec;12(6):1050-61. doi: 10.1111/acel.12130. Epub 2013 Aug 11. Aging Cell. 2013. PMID: 23837470 Free PMC article.
Preserving youth: does rapamycin deliver?
Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M. Johnson SC, et al. Sci Transl Med. 2013 Nov 13;5(211):211fs40. doi: 10.1126/scitranslmed.3007316. Sci Transl Med. 2013. PMID: 24225941 Free PMC article.
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. Johnson SC, et al. Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14. Science. 2013. PMID: 24231806 Free PMC article.
Modulating mTOR in aging and health.
Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS. Johnson SC, et al. Interdiscip Top Gerontol. 2015;40:107-27. doi: 10.1159/000364974. Epub 2014 Oct 13. Interdiscip Top Gerontol. 2015. PMID: 25341517 Free article. Review.
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.
Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M. Johnson SC, et al. Among authors: johnson bm. Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015. Front Genet. 2015. PMID: 26257774 Free PMC article.
896 results