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Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons.
Theurey P, Connolly NMC, Fortunati I, Basso E, Lauwen S, Ferrante C, Moreira Pinho C, Joselin A, Gioran A, Bano D, Park DS, Ankarcrona M, Pizzo P, Prehn JHM. Theurey P, et al. Among authors: joselin a. Aging Cell. 2019 Jun;18(3):e12924. doi: 10.1111/acel.12924. Epub 2019 Feb 21. Aging Cell. 2019. PMID: 30793475 Free PMC article.
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS. Qu D, et al. Among authors: joselin a. J Biol Chem. 2015 Dec 18;290(51):30441-52. doi: 10.1074/jbc.M115.677815. Epub 2015 Nov 4. J Biol Chem. 2015. PMID: 26538564 Free PMC article.
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Connolly NMC, et al. Among authors: joselin a. Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Cell Death Differ. 2018. PMID: 29229998 Free PMC article. Review.
The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.
Huang T, González YR, Qu D, Huang E, Safarpour F, Wang E, Joselin A, Im DS, Callaghan SM, Boonying W, Julian L, Dunwoodie SL, Slack RS, Park DS. Huang T, et al. Among authors: joselin a. J Biol Chem. 2019 May 24;294(21):8617-8629. doi: 10.1074/jbc.RA119.007941. Epub 2019 Apr 9. J Biol Chem. 2019. PMID: 30967472 Free PMC article.
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling.
Naia L, Pinho CM, Dentoni G, Liu J, Leal NS, Ferreira DMS, Schreiner B, Filadi R, Fão L, Connolly NMC, Forsell P, Nordvall G, Shimozawa M, Greotti E, Basso E, Theurey P, Gioran A, Joselin A, Arsenian-Henriksson M, Nilsson P, Rego AC, Ruas JL, Park D, Bano D, Pizzo P, Prehn JHM, Ankarcrona M. Naia L, et al. Among authors: joselin a. BMC Biol. 2021 Mar 24;19(1):57. doi: 10.1186/s12915-021-00979-5. BMC Biol. 2021. PMID: 33761951 Free PMC article.
PFTK1 kinase regulates axogenesis during development via RhoA activation.
González YR, Kamkar F, Jafar-Nejad P, Wang S, Qu D, Alvarez LS, Hawari D, Sonnenfeld M, Slack RS, Albert PR, Park DS, Joselin A. González YR, et al. Among authors: joselin a. BMC Biol. 2023 Oct 31;21(1):240. doi: 10.1186/s12915-023-01732-w. BMC Biol. 2023. PMID: 37907898 Free PMC article.
13 results