Jove R - Search Results

1

Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.

Nimmanapalli R, O'Bryan E, Huang M, Bali P, Burnette PK, Loughran T, Tepperberg J, Jove R, Bhalla K. Nimmanapalli R, et al. Among authors: jove r. Cancer Res. 2002 Oct 15;62(20):5761-9. Cancer Res. 2002. PMID: 12384536

2

Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells.

Huang M, Dorsey JF, Epling-Burnette PK, Nimmanapalli R, Landowski TH, Mora LB, Niu G, Sinibaldi D, Bai F, Kraker A, Yu H, Moscinski L, Wei S, Djeu J, Dalton WS, Bhalla K, Loughran TP, Wu J, Jove R. Huang M, et al. Among authors: jove r. Oncogene. 2002 Dec 12;21(57):8804-16. doi: 10.1038/sj.onc.1206028. Oncogene. 2002. PMID: 12483533

3

Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

Wittmann S, Bali P, Donapaty S, Nimmanapalli R, Guo F, Yamaguchi H, Huang M, Jove R, Wang HG, Bhalla K. Wittmann S, et al. Among authors: jove r. Cancer Res. 2003 Jan 1;63(1):93-9. Cancer Res. 2003. PMID: 12517783

4

Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

Nimmanapalli R, Fuino L, Bali P, Gasparetto M, Glozak M, Tao J, Moscinski L, Smith C, Wu J, Jove R, Atadja P, Bhalla K. Nimmanapalli R, et al. Among authors: jove r. Cancer Res. 2003 Aug 15;63(16):5126-35. Cancer Res. 2003. PMID: 12941844

5

Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2.

Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Mohapatra S, et al. Among authors: jove r. Cancer Res. 2003 Dec 1;63(23):8523-30. Cancer Res. 2003. PMID: 14679020

6

Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation.

Shain KH, Yarde DN, Meads MB, Huang M, Jove R, Hazlehurst LA, Dalton WS. Shain KH, et al. Among authors: jove r. Cancer Res. 2009 Feb 1;69(3):1009-15. doi: 10.1158/0008-5472.CAN-08-2419. Epub 2009 Jan 20. Cancer Res. 2009. PMID: 19155309 Free PMC article.

7

Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.

Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P, Grant S. Rahmani M, et al. Among authors: jove r. Mol Pharmacol. 2005 Apr;67(4):1166-76. doi: 10.1124/mol.104.007831. Epub 2004 Dec 29. Mol Pharmacol. 2005. PMID: 15625278

8

The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells.

Dorsey JF, Jove R, Kraker AJ, Wu J. Dorsey JF, et al. Among authors: jove r. Cancer Res. 2000 Jun 15;60(12):3127-31. Cancer Res. 2000. PMID: 10866298

9

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

Niu G, Shain KH, Huang M, Ravi R, Bedi A, Dalton WS, Jove R, Yu H. Niu G, et al. Among authors: jove r. Cancer Res. 2001 Apr 15;61(8):3276-80. Cancer Res. 2001. PMID: 11309279

10

Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.

Oshiro MM, Landowski TH, Catlett-Falcone R, Hazlehurst LA, Huang M, Jove R, Dalton WS. Oshiro MM, et al. Among authors: jove r. Clin Cancer Res. 2001 Dec;7(12):4262-71. Clin Cancer Res. 2001. PMID: 11751528

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