Julku UH - Search Results

1

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.

Svarcbahs R, Jäntti M, Kilpeläinen T, Julku UH, Urvas L, Kivioja S, Norrbacka S, Myöhänen TT. Svarcbahs R, et al. Among authors: julku uh. Pharmacol Res. 2020 Jan;151:104558. doi: 10.1016/j.phrs.2019.104558. Epub 2019 Nov 20. Pharmacol Res. 2020. PMID: 31759088

2

Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.

Svarcbahs R, Julku UH, Myöhänen TT. Svarcbahs R, et al. Among authors: julku uh. J Neurosci. 2016 Dec 7;36(49):12485-12497. doi: 10.1523/JNEUROSCI.2309-16.2016. J Neurosci. 2016. PMID: 27927963 Free PMC article.

3

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.

Julku UH, Panhelainen AE, Tiilikainen SE, Svarcbahs R, Tammimäki AE, Piepponen TP, Savolainen MH, Myöhänen TT. Julku UH, et al. Mol Neurobiol. 2018 Jan;55(1):470-482. doi: 10.1007/s12035-016-0339-8. Epub 2016 Dec 13. Mol Neurobiol. 2018. PMID: 27966077

4

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.

Svarcbahs R, Julku UH, Norrbacka S, Myöhänen TT. Svarcbahs R, et al. Among authors: julku uh. Sci Rep. 2018 Jan 24;8(1):1552. doi: 10.1038/s41598-018-19823-y. Sci Rep. 2018. PMID: 29367610 Free PMC article.

5

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases.

Svarcbahs R, Julku U, Kilpeläinen T, Kyyrö M, Jäntti M, Myöhänen TT. Svarcbahs R, et al. Biochem Pharmacol. 2019 Mar;161:113-120. doi: 10.1016/j.bcp.2019.01.013. Epub 2019 Jan 17. Biochem Pharmacol. 2019. PMID: 30660495 Review.

6

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.

Kilpeläinen T, Julku UH, Svarcbahs R, Myöhänen TT. Kilpeläinen T, et al. Among authors: julku uh. Sci Rep. 2019 Nov 22;9(1):17382. doi: 10.1038/s41598-019-54034-z. Sci Rep. 2019. PMID: 31758049 Free PMC article.

7

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner.

Julku UH, Jäntti M, Svarcbahs R, Myöhänen TT. Julku UH, et al. Int J Mol Sci. 2021 Feb 10;22(4):1777. doi: 10.3390/ijms22041777. Int J Mol Sci. 2021. PMID: 33579026 Free PMC article.

8

Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry.

Heininen J, Julku U, Myöhänen T, Kotiaho T, Kostiainen R. Heininen J, et al. J Chromatogr A. 2021 Oct 25;1656:462537. doi: 10.1016/j.chroma.2021.462537. Epub 2021 Sep 7. J Chromatogr A. 2021. PMID: 34537659 Free article.

9

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.

Eteläinen TS, Kilpeläinen TP, Ignatius A, Auno S, De Lorenzo F, Uhari-Väänänen JK, Julku UH, Myöhänen TT. Eteläinen TS, et al. Among authors: julku uh. Neuropharmacology. 2022 Nov 1;218:109213. doi: 10.1016/j.neuropharm.2022.109213. Epub 2022 Aug 12. Neuropharmacology. 2022. PMID: 35964686 Free article.

10

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.

Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: julku uh. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557

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