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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.
Winkler TW, Grassmann F, Brandl C, Kiel C, Günther F, Strunz T, Weidner L, Zimmermann ME, Korb CA, Poplawski A, Schuster AK, Müller-Nurasyid M, Peters A, Rauscher FG, Elze T, Horn K, Scholz M, Cañadas-Garre M, McKnight AJ, Quinn N, Hogg RE, Küchenhoff H, Heid IM, Stark KJ, Weber BHF. Winkler TW, et al. Among authors: kuchenhoff h. BMC Med Genomics. 2020 Aug 26;13(1):120. doi: 10.1186/s12920-020-00760-7. BMC Med Genomics. 2020. PMID: 32843070 Free PMC article.
Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.
Pflanz H, Vana K, Mitteregger G, Renner-Müller I, Pace C, Küchenhoff H, Kretzschmar HA, Wolf E, Weiss S. Pflanz H, et al. Among authors: kuchenhoff h. J Mol Biol. 2009 May 15;388(4):721-9. doi: 10.1016/j.jmb.2009.03.045. Epub 2009 Mar 24. J Mol Biol. 2009. PMID: 19324055
At the terminal stage, transgenic mice revealed significantly reduced proteinase-K-resistant PrP levels by 71% compared to wild-type mice. Our results recommend the laminin receptor decoy mutant as an alternative therapeutic tool for treatment of transmissible spongiform e …
At the terminal stage, transgenic mice revealed significantly reduced proteinase-K-resistant PrP levels by 71% compared to wild-type …