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Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence.
Ungvari A, Kiss T, Gulej R, Tarantini S, Csik B, Yabluchanskiy A, Mukli P, Csiszar A, Harris ML, Ungvari Z. Ungvari A, et al. Geroscience. 2024 Jun;46(3):3105-3122. doi: 10.1007/s11357-023-01042-7. Epub 2024 Jan 6. Geroscience. 2024. PMID: 38182857 Free PMC article. Review.
Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain.
Gulej R, Nyúl-Tóth Á, Ahire C, DelFavero J, Balasubramanian P, Kiss T, Tarantini S, Benyo Z, Pacher P, Csik B, Yabluchanskiy A, Mukli P, Kuan-Celarier A, Krizbai IA, Campisi J, Sonntag WE, Csiszar A, Ungvari Z. Gulej R, et al. Geroscience. 2023 Oct;45(5):2983-3002. doi: 10.1007/s11357-023-00870-x. Epub 2023 Aug 29. Geroscience. 2023. PMID: 37642933 Free PMC article.
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain.
Ahire C, Nyul-Toth A, DelFavero J, Gulej R, Faakye JA, Tarantini S, Kiss T, Kuan-Celarier A, Balasubramanian P, Ungvari A, Tarantini A, Nagaraja R, Yan F, Tang Q, Mukli P, Csipo T, Yabluchanskiy A, Campisi J, Ungvari Z, Csiszar A. Ahire C, et al. Aging Cell. 2023 Jul;22(7):e13832. doi: 10.1111/acel.13832. Epub 2023 May 26. Aging Cell. 2023. PMID: 37243381 Free PMC article.
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
Owens CD, Mukli P, Csipo T, Lipecz A, Silva-Palacios F, Dasari TW, Tarantini S, Gardner AW, Montgomery PS, Waldstein SR, Kellawan JM, Nyul-Toth A, Balasubramanian P, Sotonyi P, Csiszar A, Ungvari Z, Yabluchanskiy A. Owens CD, et al. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H924-H935. doi: 10.1152/ajpheart.00616.2021. Epub 2022 Mar 25. Am J Physiol Heart Circ Physiol. 2022. PMID: 35333116 Free PMC article.