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Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.
VanAlstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM. VanAlstine MA, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2128-33. doi: 10.1016/j.bmcl.2013.01.117. Epub 2013 Feb 8. Bioorg Med Chem Lett. 2013. PMID: 23434225 Free PMC article.
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.
Wentland MP, Jo S, Gargano JM, VanAlstine MA, Cohen DJ, Bidlack JM. Wentland MP, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7340-4. doi: 10.1016/j.bmcl.2012.10.081. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2012. PMID: 23142613 Free PMC article.
Aminothiazolomorphinans with mixed κ and μ opioid activity.
Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. Zhang T, et al. J Med Chem. 2011 Mar 24;54(6):1903-13. doi: 10.1021/jm101542c. Epub 2011 Feb 25. J Med Chem. 2011. PMID: 21351746 Free PMC article.
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB. Conroy JL, et al. Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7. Nat Neurosci. 2010. PMID: 20139973 Free PMC article.
27 results